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CORONA VIRUS GUIDANCE

From a Compendium of Research. Wishing health, success, wisdom and the opportunity for shared Human priority For Leaders, Nations, Population, Groups, Services Performers, Practitioners, Philanthropies, therapeutics development organizations, Health Consumers, Researchers, and Industry. 

This page has 1 visual and 6 or more documents.

These analyses have found that there are 12, 20, or 50 factors that have been known since as early as 1861 or even earlier, that have been systematically omitted in care and Human priority that are required for all disease, detrimental behavior generally, sudden adverse health events, microbial, viral, bacterial and other conditions Such factors are even required for genetic disease, impairment, pain, persistent injury, detrimental aspects of aging, scar tissue, and aspects of anatomy which have been removed not being able to spontaneously regenerate themselves to the extent that managing these factors supplementally also was correlated with cessation of abated vital being and abated biological rhythms becoming spontaneously transformed into functional biological systems with conscious vital being. This pandemic will conclude, even if the people and the systems of the earth have to finally move unison to the priority of Humanity, themselves, each other and circumventing the nuances of opinion which have beenan impedance to Human priority.

These 12, 20, or 50 factors including Homocysteine and iNOS because they are allowed to persist even during care interventions in the primary care, outpatient, inpatient, emergency or essential care setting result in the impairment of an enzyme known as PEMT which results in almost all detrimental physiological and behavioral outcomes in civilization because it is an important enabler of social function at the cellular level and organisms level essential to anatomy, physiology, behavior and the functions that are required to produce and be within civilization. These analyses found that these allowed factors accumulated with choline deficiency, disease, exposure to energy and communications fields, exposure to atmospheric particulate factors, bacteria, required by viruses, chlorine, fluorine, being restrained, toxins, many drugs and therapeutics, and other factors.  

Together, these factors suppress species specific physiological, immunological and developmental pathways that allow population and environmental level similarities in different species of organism to occur, and this suppression performs as a gateway for interspecies movement and development o disease, pathogens, microbes, bacteria, viruses, and other organisms. These factors enable systematic testing and learning of what factors can be manipulated to enable on demand utilization of  facilities that manage detrimental Human outcomes such that causality can be obscured or attributed to Humans as well as in a way that has caused such levels of detrimental behavior and physiological outcomes since 1861 that even every geopolitical conflict can be attributed to these factors since 1878. Most importantly, a closer review of these factors demonstrate that the omitted 12, 20 or 50 factors, or two in particular, are primary mechanisms used by one of the most detrimental sociopolitical factions or regimes know to the Human experience.

No administration or person in existing generations could likely be attributed even participation in the decision of the early 1900s and concluding 1800s, or earlier, which produced a system in this regard which emerged to benefit from allowed detriment to Humanity. However, every Human should have the opportunity to understand what has been done in this regard, and should be allowed to begin to build lives unencumbered by conditions, health statuses and diseases that should have been resolved centuries ago. .There are three documents presented on this web page. 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Coronavirus Data  for Clinicians, therapeutics Development and afflicted

(Special priority in managing the diverse causes of iNOS is recommended including covering electrical outlets in emergency rooms, inpatient, outpatient, provider office, work, dwellings and homes. alleviating Choline deficiency. managing bacterial iNOS expression with Broad Spectrum Antibiotics or phenotyped Antibiotic Selection. Not Restraining patients and the afflicted. removing your name and likeness, as well as photos, addresses, phone numbers, and device information from any website. Turning off the ancillary communications on mobile phones, turning off mobile devices or phones, as well as unplugging, removing batteries, and covering in metabolic containers as well as with aluminum foil both mobile phones, mobile devices or identification that has electronic strips, chips or readable information used in electronics. Turn off wireless networks, lights, and cover any electronic, electrical or other devices with EMF protection covering, quilting, etc.  Duct tape can be used to cover electrical outlets, and devices can be plugged in through the tape, but taping around the device plugin can be helpful.  Only using or drinking filtered water without Chlorine and Fluorine. Filtered air which has particulate factors removed is recommended. Disable GPS and Telemetry or Location on all phones and computing devices. EMF inhibiting netting or blankets draped over bedding, or EMF inhibiting Curtains or doorway draperies are also recommended. Avoid therapeutics that increase Homocysteine, are prodrugs, or which increase iNOS, except those which either inhibit Homocystiene and iNOS, or those which are designed to inhibit Homocysteine or iNOS. RedSage/Danshen/SalviaMiltiorrhiza, Choline, S-Methylmethionine, 6s 5678 tetrahydrofolate, Trimethylglycine, Dimethylsulfoxide, Methylsulfonylmethane, Curcumin, Irinotecan and Berberine are a powerful iNOS/Homocysteine reducing medley. NAD+ also enhances S-AdenosylHomocysteine Hydrolase activity to prevent trapping of S-Adenosyl Homocysteine. Covering upper back, whole back, and back of neck with cardboard, durable emf inhibiting structures, or durable factors wrapped in emf protection material. 
1. Nitric Oxide Donors such as S-nitroso-N-acetylpenicillamine (SNAP) is an example of a Nitric Oxide Donor.
1.5 Anbitiotics decrease inos from microbe lipopolysaccharide.
2.Choline, Melatonin, Aminoguanidine, Curcumin, Hydroxychloroquine, other inhibitor of iNOS.
2.5 cardboard/fold paper/EMF protection material taped across the upper back behind lungs, covering the spine, back of neck between back and head, using thickly folded cloth to cover the circumference of the neck alleviate inflammation/pain/cough. Cover upper back/lower neck with hand during energy.
3. Cover electrical outlets, surge protectors, power strips. Turn off lights and mobile/wireless networks/devices. Place EMF protection stickers/covering/dots/paint on care/electrical/wireless devices/radios/phones/TVs. Remove Chlorine and Fluorine from water.
4. Don't use PCSK9 inhibitors, HMG-CoA reductase inhibitors.  Risk factors = NOS2a gene variant and PEMT enzyme Polymorphism. 
5.  Choline, Tetrahydrobiopterine(Along with Sapropterin and not only instead of), L-Arginine, Iron, Calcium and Vanadium, as well as 6s 5678 Tetrahydrofolate. 
6. Superoxide Dismutase, Catalase, Glutathione, Peroxyredoxin-6, Cystathionine, Cystathionine, N Acetyl L Cystine, Glutathione Peroxidase, Vitamin C and 33DMB.  
7. Choline, S-Methylmethionine Dimethyl Sulfoxide, Trimethylglcyine, 6s 5678 Tetrahydrofolate, Selenium, Red Sage as Denshen or Salvia Milthiorhizza, B12 Methylcobalamin, B6, Niacin, Pantothenic Acid, Thiamin, Riboflavin, Biotin, and all B vitamins, Dimethylacetothetin. Low levels of S-Adenosyl Methionine and Selenomethionine. 
8. Berberine or an AP1 inhibitor.
9. Curcumin or an SP1 inhibitor.
10. Bindarit,  curcumin, or an MCP1 inhibitor
11. Vitamin E, aspirin, rofecoxib, and celecoxib , curcumin/Irinotecan
12.  N-acetyl L Cysteine along with Magnesium and Citrate or Mangesium Citrate, aminoguanidine, Quercetin, Morin, and kaempherol.
13. 33DMB, Grapeseed oil, Grapeseed Extract, Olive Oil, Balsamic Vinager, as well as a Broad Spectrum Antibiotic during an Emergency, or Pre/pro/post Biotics, or laxatives and granularized foods.
14. Choline supplementation, Managing Methylglyoxal and Managing levels of Lacatate, as well as a regimen of Probiotics Bifidobacterium breve Yakult and Lactobacillus casei Shirota along with galacto-oligosaccharide as a prebiotic.
15. Filtered water without chlorine/fluorine. Use Magnesium Citrate, Magnesium or Citrate, Potassium Citrate or Potassium and Citrate.
16. Pregnenolone or Choline Kinase inhibitor.

Prevention, Therapeutics, Safe Practices, and Managing the Pandemic, Navigating the old ghosts and relics of hundreds and thousands of years.

 

Complimentary Therapy for Microbial, SARS, Corona and Influenza Affliction

A. Summary, Therapeutics for Corona Virus Pathology.

Stay at Home orders and Social Distancing Requirements may be having a slowed effect because the Home and Dwellings are Major Sources of Energy fields, Chlorine and Fluorine, all of which increase the major detrimental factor in Coronavirus Pathology iNOS. iNOS in the Home is a major contributor to age correlated pathology and pathology of a progressive nature regardless of age, such that not managing sources of iNOS in care setting and in the Home increases risk.     

Nitric Oxide Donors Inhibit the pathology of Corona Virus. S-nitroso-N-acetylpenicillamine (SNAP) is an example of a Nitric Oxide Donor.

Antibiotics have been effective because they decrease Bacteria and bacterial membranes pervasively exhibit Lipopolysaccharide which is an innate activator of iNOS. Similarly, therapeutics pervasively have the potential of increasing Homocysteine as well as increasing iNOS. Antibiotics and Therapeutics which have stronger therapeutics effect, as close to the core of empirical causal factors to all pathology, and with the comparative lowest expression of iNOS and comparative lowest increase to Homocysteine levels. It is optimal to use therapeutics which decrease iNOS and decrease Homocysteine.

Hydroxychloroquine inhibits iNOS, at least the iNOS produced from a particularly Interleukin-1b pathway. However, iNOS is also produced in other interleukin pathways, other pathways, from inhibition of PEMT1/2/3, energy fields and communication fields, artificial light, chlorine such as in water, fluorine such as in water, microbial or bacterial lipopolysaccharide, bona fide injury, inflammation otherwise, viruses through Macrophage activation, Macrophages through stimulation of other cellular entities, change in gravity such as when astronauts return from space, massive deterioration of cellular entity density correlated to lysis as well as necrosis and apoptosis occurring from choline deficiency as well as C reactive protein and Protein C activity along with Cellular, Humoral, Adaptive, Innate and Complements immunological function. iNOS, ephemerally exhibited, beneficially flushes the cytosol of microbes and provides Nitrogen molecular species for use within the plasma membrane interstitial space to increase the turgor of cellular entities in tissues which are depleted of adequate number of cellular entities per micrometer to prevent systemic structural collapse and disorientingly complex deterioration of numerous systems of physiology known as the syndrome M.O.D.S. The Hyperactivation of immunological systems and usage of Immunological systems to stop tissue deterioration begin near birth to manage the effects of choline deficiency and is exhibited during inflammatory syndrome such as Pulmonary Distress Syndromes associated with Microbial Pathology because without adequate Choline and DHA enriched Phosphatidylcholine derived from PEMT1, PEMT2, and PEMT3, the Immunological System must balance maintaining physiological structure with exhibiting cellular Immunological function which oppositely enable apoptosis as well as necrosis with cellular immune function compared to preventing these when maintaining physiological structure. Chloroquine, however, according to the literature, does not inhibit iNOS. Similarly, this analyses was not able to reasonably and efficiently ascertain in the data, clinical information, or literature if Hydroxychloroquine inhibits iNOS transcriptionally, Enzymically, or if it inhibits a pathway to iNOS express or if it inhibits a pathway to iNOS activation. Thus, therapeutic teaming may be optimal.

Homocysteine above 6 or 7 Micromoles per liter, S-adenosyl Homocysteine above 0.012 Micromoles per liter, iNOS, uncoupled NOS, TrimethylamineNOxide, Deficient choline obtainment, inadequate choline transport and impaired choline synthesis, all of which result from or cause impairment of the enzyme PEMT and all of its benefits, is the cause of every disease and almost every detrimental behavioral or physiological outcome. These are allowed to progress to numerous diverse other factors that can enable therapeutics development, at the expense of Human health and at the expense of health services workers whom have about a two decade lower typical span of being than the general population according to some studies. If these factors are managed and the causes of the factors are managed, Coronavirus and its pathology does not occur or is abated. The way in which this epidemic has emerged has been through populations which have had these causal factors chronically neglected such as the aged whom have these factors ignored to generate consistent revenue, recidivism and sustain inaccurate opinion about human behavior and Human span of being. The success of Hydroxychloroquine or other factors are likely to be conformed to be through inhibition of iNOS, AP1, SP1, MCP1, C Reactive protein, and other factors among these empirical causal factors.

The solutions seems to always be an expensive factor with a business interest behind it, instead of Choline, Curcumin, Berberine, or biological names such as Catalase, Tetrahydrobiopterin, etc. These biological names are considered to be nuances of basic science that are not a part of medicine, such that basic science is often considered to be a distant concept from health services practice. Interestingly, there are thousands of natural and pharmacological factors that inhibit iNOS, provide choline, enable PEMT function, inhibit AP1, manage SP1, prevent Uncoupling of NOS, etc, but the system of medicine produces guidelines that prevents a reasonable Human from querying the clinical and research literature simply seeing if a drug or natural molecule inhibits one of these empirical causes of disease and then implementing the drug or natural molecule. The system of medicine waits while Humans perish, comes up with strategy that ignores the incipient and empirical causes of disease, and implements a typically business solution that uses a drug regardless of it it affects any of the empirical causes of disease and preferring that a molecule that is effective is found that is most distant from these empirical factors because the secrets of the Industry and how it makes money can be, to a system, more important than Human vital being. Humans should be the priority in anything that Humans do, consider, perform, build, operate or endeavor.

It is very relevant to for any health facility, health services, care provider, manager of any dwelling or people in any dwelling to prioritize covering their electrical outlets, power outlets, surge protectors or power strips, light switch panels, outlets for any communication device, as well as it is imperative to use EMF safe covering for all electrical devices, electronics, or appliances using batteries or electricity. It is also important for all local, municipal and regional entities to prioritizing coating all energy and communication lines or wiring, as well as covering power stations, generally, but particularly in areas of dense microbial pathology, dense viral affliction, or epidemiological epicenters in any regard. Computing devices and wireless communications devices, all should have all unnecessary communications protocols disabled such as blue tooth, wifi, GPS, IoT protocols, Infrared and others, particularly in or near care settings or in or near vulnerable populations.

Melatonin, Aminoguanidine, Curcumin, and pharmacological iNOS inhibitors exist as potent and selective iNOS inhibitors. Melatonin at 20 mg per kg of anatomical mass to 60 mg per kg of Anatomical mass inhibits iNOS and Lipid Peroxidation in experimental small nonhuman models of Lipopolysaccharide induced iNOS expression and microbial affliction of Pulmonary and Hepatic tissue, specifically disrupting the cycle of multiple organ distress syndrome and Pulmonary distress syndrome observe in models of Corona, Influenza and other viral affliction. The inhibition of iNOS and Lipid Peroxidation occurred through inhibition of iNOS gene transcription, while also linking iNOS clearly to cascade of Uncoupling of Nitric Oxide Synthase, uNOS, and linking iNOS and uNOS to Superoxide, H2O2, Peroxynitrite, Hypochlorite and Peroxidation of Lipids. Melatonin counteracted canonical Endotoxemia features including alleviating increases in Aspartate, Alanine, Aminotransferases which have to be increased to assist in managing detoxification as well as enable Methylation pathway supply of Trimethylsulfonium/Trimethylselenium/Trimethyltellurium/Methyl Factors, as well as alleviated increases in Alkaline Phosphatase, Creatinine, Urea, Uric Acid, and iNOS RNA, all clearly presenting the Melatonin protects Pulmonary, Hepatic, and Renal tissues to disrupt septicemia, endotoxemia, and multiple organ system deterioration associated with less than optimal outcomes. 65 Percent decrease in iNOS expression occurred with 60 mg per kg of anatomical mass instrumentation of Melatonin. Curcumin inhibits iNOS both at the transcription level and through increasing the deterioration of iNOS enzymes after transcription while Curcumin and its major metabolites also inhibit ERK 1/2. Another study clearly establishes that Curcumin inhibits small nonhuman mammary gland iNOS expression resultant of Lipopolysaccharide, Lipoolysaccharide increases iNOS by 2000 percent, increase in iNOS was accompanied by deactivation of eNOS which clearly confirms the depletion of L-arginine and Ca2+ by INOS as a deactivator of eNOS/nNOS, Curcumin scavenged Nitric Oxide Radicals such as Peroxynitrite, and after Lipopolysaccharide was removed, curcumin did not diminish intermittent upregulation of iNOS presumably in its biologically intended role to flush microbes from Cytoplasm, supply reactive molecules to the plasma membrane interstitial space and help enabled strength of cellular entities during massive cellular lysis, apoptosis, and necrosis from injury, immunological function, and choline inadequacy. The protective effect of curcumin against inflammation, oxidation, microbes, neurological deterioration, colon pathology, neoplasm, and mutations of genetic material were attributed to its preventing of NF kB from being translocated from the cytoplasm generally or Cytosol into the Nucleus requiring iNOS to be expressed from very specific pathways instead of allowing iNOS from being expressed as a general inflammatory response commandeerable by pathogens and pathogenic processes. Resource. FASEB J. 1999. Sep; 13(12):1537 to 46. Resource. 10.1016/j.intimp.2010.11.013. INT Immunopharmacol. 2011. Feb; 11(2);179-86. Resource. Nitric Oxide. 2000. OCt; 4(5):505 to 515. Resource. 10.3892/mmr.2014/3079.

PCSK9 inhibitors may enhance susceptibility by inhibiting Cholesterol Receptors that are correlated with decreased virulence of Pathogens. Cholesterol management factors such as HMG-CoA reductase inhibitors, also decrease Isoprenoid Synthesis which can impair natural inhibitors of AP1. In some areas, Heterozygous one strand of DNA at 75 percent and Homozygous two strand at 50 percent, describes the level of PEMT Genetic Polymorphism, which explains differing susceptibility to pathology, particularly as every one of the indicators presented here, in some way, inhibit PEMT. These may describe differences in susceptibility.

Choline, Tetrahydrobiopterin(Along with Sapropterin and not only instead of), L-Arginine, Iron, Calcium and Vanadium, as well as 6s 5678 Tetrahydrofolate all assure Nitric Oxide Production.

Selective inhibition of Inducible Nitric Oxide Synthase assists Nitric Oxide Production because pervasively, viruses modulate iNOS expression to their benefit, but iNOS depletes Calcium and L-arginine required for Endothelial and Neuronal Nitric Oxide Production as well as causes constriction of the Caveolae where Immunological Communication and function largely occurs. Curcumin or other selective inhibitors of Inducible Nitric Oxide Synthase are known in the clinical literature. iNOS expression occurs persistently and detrimentally resultant of Choline Deficiency requiring supplementation, as well as occurs resultant of exposure to electrical fields such as lights, wireless communication, uncovered electrical outlets, and energy from devices in the home, care setting and outside environment. These should be managed in the home and care setting. Unfiltered water can have chlorine and fluorine, both of which cause iNOS expression.

Homocysteine is a detrimental component of all pathology. Choline, S-Methylmethionine Sulfonium, Trimethylglcyine, 6s 5678 Tetrahydrofolate, Selenium, Red Sage as Denshen or Salvia Milthiorhizza, B12 Methylcobalamin, B6, Niacin, Pantothenic Acid, Thiamin, Riboflavin, Biotin, and all B vitamins, as well as the hard to obtain Dimethylethin. low levels of the widely available S-Adenosyl Methionine and Selenomethionine are recommended only with these other factors. Together, these can reduce Homocysteine to below the required 6 or 7 Micromoles per liter, or lower.

Uncoupling of Nitric Oxide Synthases are essential to pathology including infarct and inflammation. Superoxide Dismutase, Catalase, Glutathione, Peroxyredoxin-6, Cystathionine, Cystathionine, N Acetyl L Cystine, Glutathione Peroxidase, and Vitamin C. These should be utilized along with Choline, Tetrahydrobiopterin, L-Arginine, Iron, Calcium and Vanadium, as well as 6s 5678 Tetrahydrofolate.

AP1 is widely utilized by viruses, including the Corona Virus. Berberine or an AP1 inhibitor are widely effective in inhibiting AP1.

SP1 is widely utilized by viruses, including the Corona Virus. Curcumin or an SP1 inhibitor or widely effective in inhibiting SP1.

MCP1 is utilized by viruses, including the Corona Viruas. Bindarit inhibits MCP1.

C-Reactive Protein is an important factor in inflammation, including Pulmonary inflammation, and is inhibited by Vitamin E, aspirin, rofecoxib, and celecoxib as well as by curcumin.

Methylglyoxal is regarded as the best indicator of sepsis and participates in complications. Methylglyoxal is scavenged by N-acetyl L Cysteine along with Magnesium and Citrate or Magnesium Citrate. Methylglyoxal can also be managed using aminoguanidine. Adding Methylglyoxal Quercetin, Morin, and kaempherol, Methylglyoxal to either N Acetyl L Cysteine and Aminoguanidine prevents Advanced Glycation End Products.

TrimethylamineNOxide is most prevalent cause of Stroke, complications and abated vital being by progressive or natural causes. 33DMB, Grapeseed oil, Grapeseed Extract, Olive Oil, Balsamic Vinegar, and a Broad Spectrum Antibiotic during an Emergency, as well as Pre/pro/post biotics, all managed TrimethylamineNoxide.

D Lactate and D Lactic Acid is an esoteric factor causing abated vital being and can be managed in several ways. Anecdotal information in the clinical journals suggests Probiotics Bifidobacterium breve Yakult and Lactobacillus casei Shirota along with galacto-oligosaccharide as a prebiotic. D Lactate can be managed by assuring Choline availability and assuring the function of PEMT, which assures that P53 is inhibited and assures that Glycolysis pathway is functional. Inhibiting D Lactate Dehydrogenase can be strongly therapeutic for Neoplasms and can prevent production of D Lactate as was as prevent production of Pyruvate by Lactate Dehydrogenase in Neoplasms. Managing Methylglyoxal can prevent its translation into D Lactate. Managing levels of Lactate prevent its translation into D Lactate.

Hyperoxularia or Oxalates can be managed using drinking Water that does not have fluorine or chlorine in it. Oxalates can be managed also with Magnesium Citrate, Magnesium or Citrate, as well as with Potassium Citrate or Potassium and Citrate. Both Potassium and Magnesium along with Citrate and along with Water can be used in some combination.

The summary of these factors are important, because when unmanaged, these nuances of Corona Virus activity, like all pathology, disease and detrimental behavior, merely focus on impairing the activity of the enzymes PEMT1, PEMT2 and PEMT3 which integrates Hydride, Hydride exhibited in Methyl Groups and Methyl Groups within Choline into Phosphatidylcholine and producing ether linked fatty acids with biosynthesis potential and antiinflammatory potential. Similarly, these same factors, unmanaged, cause upregulation of the highly inflammatory CDP Choline Pathway which is parallel to the CDP Ethanolamine pathway that supplies primarily the PEMT1, PEMT2 and PEMT3 with substrate but also can supply its parallel pathway with some substrate. This paradox is antihistamine compared histamine pathway, and the inflammation is largely the result of Xenobiotic, allergic and inflammatory response. However, upregulation of CDP Choline pathway potentiates increase Phosphatidylserine and Increased Phosphocholine, such that phosphocholine potentiates activation of platelets and the polarity of phosphatidylserine potentiates coagulation activity, while these supply phosphatidylcholine that is less densely comprised of OMEGA-3 Fatty Acids and less densely comprised of ether linked as well as extended length arachidonate fatty acids. Resultantly, increased ceramide can occur from Phosphatidylserine that is not depleted by Phosphatidylserine decarboxylase to generate Phosphatidylethanolamine because PEMT may not deplete newly synthesized Phosphatidylethanolamine at levels high enough to cause adequate circulation of phosphatidylserine. Phosphatidylserine and Phospholipids then can be directed toward ceramide, then sphingosine 1 phosphate, followed by a decision in which either inflammatory G proteins are produced or S1P Lyase depletes Sphingosine 1 phosphate into Phosphoethanolamine pathway substrates and Hexadecenal. Although this inflammatory pathway seems detrimental, it is useful for xenobiotic, allergic, histamine and injury response. iNOS is expressed similarly as a result of either massive apoptosis from choline deficiency, massive tissue depletion during cellular lysis, immunological function causing apoptosis and necrosis, injury, particularly deep tissue injury, change to gravitational fields such as with astronauts emerging from nongravitational environments, as a response quantum influences like energy fields to make physiology be "more here in this instance of time," from microbial polysaccharide, resultant of viral pathology including Macrophage expression of iNOS and Macrophage stimulation of iNOS in other cellular typologies, result of Chlorine and Fluorine. iNOS expression can occur resultant of particular therapeutics including those which are used for pulmonary, cardiac, viral and other pathology. Both iNOS and Homocysteine can be increased in the typical context of therapeutics, increasing the incipient and empirical causes of inflammation, disease and differentially exhibited detrimental behavior.

A choline kinase inhibitor, such as a pharmacological Choline Kinase Inhibitor, or a natural inhibitor of Choline Kinase such as Pregnenolone, or inhibition of the upregulators of the CDP Choline Pathway many of such upregulators are presented in this summary, also inhibits the inflammation pathways resulting Corona Virus Pathology. Choline Kinase is upregulated at three or more junctures in development, including during gestation and including at birth when rapid changes to pulmonary tissue is required as response to newly emerge pulmonary function and as a defense to environmental factors incurred through pulmonary function.

Thus, it must be considered how and why iNOS expression is occurring in pulmonary tissue. Inhibiting iNOS and perhaps allowing it to be expressed intermittently with a therapeutic pause, if enabled at all, may abate viral pathology, but it is still important to be sure that iNOS is not being expressed because of the other reasons presented here, including deterioration of the ratio of cellular entities per micrometer of tissue, Choline deficiency, energy fields, communication fields, chlorine, fluorine, particulate factors in the environment, viral pathology, overactivation of immunological function, hyperactivation of Immunological function because the Caveolae has become constricted, Gravitational influence, Microbial or Bacterial Lipopolysaccharide. Thus, Antibiotics can be useful, particularly when they do not increase homocysteine and do not increase iNOS. Thus, using filtered water to remove particular factors, chlorine and fluorine is indicated. Thus, covering all the power outlets and using only EMF safety covered lights and using emf protection stickers and material for devices, all are indicated. Similarly, reconstituting the choline pathways as presented in the recommendations above are also indicated.

Also, if ventilators are not available, covering the backs, upper back and back of neck with cardboard or EMF inhibiting material reinforced by thick paper or cardboard, as well as covering necks with neck stabilization device similar to that used in neck injury or by loosely wrapping the neck with thickly folded towel will stop the way that energy fields are primary influences in causing the most progressed pulmonary inflammation. It may useful to use tape to stabilize the back and might be useful to cardboard across the front of the chest with adequate looseness to not constrict pulmonary function. similarly, regularly covering in successive 30 second instances eyes, ears, uncovered upper back of neck and head, and pinching nostrils while the mouth is open and unimpeded, all disrupt the entry of atmospheric fields and energy fields. These fields may cause swelling of the endothelial areas, hasten uncoupling of iNOS and make depletion of Ca2+ and depletion of L Arginine more rapid and complete if not managed proactively. Observationally, these should result in improved deeper stable relaxed breathing within a 30 seconds or more, particularly after covering neck, back of neck and back. It is possible to order EMF protection blankets, covering, tape, and paint from internet websites and specialty stores on the internet.

Stay at Home orders and Social Distancing Requirements may be having a slowed effect because the Home and Dwellings are Major Sources of Energy fields, Chlorine and Fluorine, all of which increase the major detrimental factor in Coronavirus Pathology iNOS. iNOS in the Home is a major contributor to age correlated pathology and pathology of a progressive nature regardless of age, such that not managing sources of iNOS in care setting and in the Home increases risk. iNOS contributes to uncoupled Nitric Oxide Synthase, Superoxide, Hydrogen Peroxide, Peroxynitrite, Hypochlorite, TrimethylamineNOxide, as well as inhibition of PEMT, each of which are required in every Human disease, are the constitutive nuances of infarct and tissue deterioration with abated vital being, and promote systemic instability and Multiple Organ Distress Syndrome. Unless energy is managed in the Home and care setting, these factors can transform the care setting and Home setting into nuances of progressive pathology. iNOS from the factors describe here have emerged in civilization i precise correlation with exhibition of seasonal influenza, viral and other conditions associated with pulmonary dysfunction and general pathology otherwise.   

Homocysteine above 6 or 7 Micromoles per liter, S-adenosyl Homocysteine above 0.012 Micromoles per liter, iNOS, uncoupled NOS, TrimethylamineNOxide, Deficient choline obtainment, inadequate choline transport and impaired choline synthesis, all of which result from or cause impairment of the enzyme PEMT and all of its benefits, is the cause of every disease and almost every detrimental behavioral or physiological outcome. These are allowed to progress to numerous diverse other factors that can enable therapeutics development, at the expense of Human health and at the expense of health services workers whom have about a two decade lower typical span of being than the general population according to some studies. If these factors are managed and the causes of the factors are managed, Coronavirus and its pathology does not occur or is abated. The way in which this epidemic has emerged has been through populations which have had these causal factors chronically neglected such as the aged whom have these factors ignored to generate consistent revenue, recidivism and sustain inaccurate opinion about human behavior and Human span of being. The success of Hydroxychloroquine or other factors are likely to be conformed to be through inhibition of iNOS, AP1, SP1, MCP1, C Reactive protein, and other factors among these empirical causal factors.

The solutions seems to always be an expensive factor with a business interest behind it, instead of Choline, Curcumin, Berberine, or biological names such as Catalase, Tetrahydrobiopterin, etc. These biological names are considered to be nuances of basic science that are not a part of medicine, such that basic science is often considered to be a distant concept from health services practice. Interestingly, there are thousands of natural and pharmacological factors that inhibit iNOS, provide choline, enable PEMT function, inhibit AP1, manage SP1, prevent Uncoupling of NOS, etc, but the system of medicine produces guidelines that prevents a reasonable Human from querying the clinical and research literature simply seeing if a drug or natural molecule inhibits one of these empirical causes of disease and then implementing the drug or natural molecule. The system of medicine waits while Humans perish, comes up with strategy that ignores the incipient and empirical causes of disease, and implements a typically business solution that uses a drug regardless of it it affects any of the empirical causes of disease and preferring that a molecule that is effective is found that is most distant from these empirical factors because the secrets of the Industry and how it makes money can be, to a system, more important than Human vital being. Humans should be the priority in anything that Humans do, consider, perform, build, operate or endeavor.

Catalase, Superoxide Dismutase, NAcetylLcysteine, Glutathione, 6s 5678 tetrahydrofolate, Tetrahydrobiopterin, Iron, Zinc, Molybdenum, peroxiredoxin and Dimethyl Sulfoxide, would round out this supplemental regiment and make it no worse than a mild cold if not abated pathology completely.  Covering all of the electrical outlets in the ICU, inpatient rooms, emergency admittance, and emergency rooms with duct tape and Taping cardboard to the upper back and lower neck, turning off the lights, as well as covering the neck with thickly folded towel would relieve the major source of iNOS expression which is energy and communications fields. This should stabilize much of the pulmonary statuses and free up ventilators. However, together, all of these recommendations would probably relieve the epidemic. However, this $25 dollar solution might not even be considered in context where they are looking for billion dollar rocket ship solutions.

Also, most drugs or therapeutics increase S Adenosyl Homocysteine and increase Homocysteine, as well as can increase iNOS, and both of these are among the most potent inhibitors of the enzyme PEMT1, PEMT2 and PEMT3. Every disease and every factor discussed in this document or article directly or indirectly inhibits or impairs PEMT catalytic activity, while every pathogen and every disease requires that PEMT be inhibited in order for that disease, pathology or pathogen to emerge, persist, progress, impart detriment and elude physiological capabilities of prevention and alleviation. The therapies being used, unless the decrease Homocysteine and decrease iNOS, as well as inhibit AP1, SP1, MCP1, C Reactive Protein, IDO, Thrombin, and TrimethylamineNOxide, have the potential of decreasing some factors but only increasing the balance of pathology by increasing iNOS and Homocysteine, as well as causing uncoupling of Nitric Oxide Synthases.

S Adenosyl Homocysteine above 0.012 um/L, Homocysteine above 6 or 7 um/L, iNOS other than ephemerally, inhibition of the enzyme PEMT1, PEMT2 and PEMT3, resultant upregulation of the CDP Choline Pathway and inhibition of the CDP Ethanolamine Pathway, Sulfide inadequacy, causal/resultant factors including Choline deficiency, Methyl Group deficiency, Hydride inadequacy,  iNOS, AP1, SP1, MCP1, C Reactive Protein, IDO or Indoleamine 2,3 Dioxygenase, the most pervasive cause of TrimethylamineNOxide, an ancillary symptom of stroke known as Thrombin, methylglyoxal, hyperoxularia, L lactate/lactic acid, D Lactate/Lactic acid, as well as uncoupling of Nitric Oxide Synthase and Depletion of NAD+/NADH, are the core causes of almost every disease if not every disease. Every Pathology or Pathogen uses these emerge, persist, progress, impart detriment and elude physiological prevention and alleviation. These branch into many thousands of molecular, metabolic, structural, functional and behavioral anomalies which are used as opportunities for products, services, and control of consumer behavior, producing all of the outcomes observed in civilizations.

These core factors have often been omitted in care because they enable hundreds of thousands of business opportunities, services and products. Covid persists as an epidemic because the established status quo is looking for ways to manage Covid using these branched diverse products and services instead of acknowledging, divulging and treating as well as managing these incipient and empirical causalities.

Beginning in gestation, the brain, metabolism, physiology, memory, conditioning,, suprachiasmic Nucleus function, rewards system, and suggestibility, all are influenced in pathogenic ways by Choline inadequacy, and impaired PEMT function. The result is the incipient Human priorities enabled by PEMT which is a strong reason the cellular entities exhibit social behavior to produce tissues, structures, organs and physiology as well as the strong basis for Social Behavior between organisms, become diminished and replaced with external associations, stimuli, imposed responses, and commandeering of innate association of shapes, smells, colors, pheromones, sounds, tastes, etc, that would lead to choline in nature are, instead, used to direct Humanity to have inclination, priorities, behavior, cognition and function that prioritizes systems and uses consistent upon from external systems supplantingly of any intrinsically coherent motivation.

These are the reason every sales and marking campaign are successful. Pharmacological entities know this because they expend 50% of revenue, according to some studies, on marketing sand sales,, as well as advertising, showing that they know that these susceptibilities are competed for by systemic and business interests. Every disease, behavioral health, psychiatric, or other condition, as well as detrimental behavior, is correlated with these causal factors and has been well established since the 1950s or earlier. However, although it can be shown the these factors are allowed continue unalleviated beginning with gestation, most therapeutics contributed to these core of pathogenic factors in away that contributes to every detrimental nuance of aging because these factors increase with age and are correlated to all aspects of age associated pathology, these continue to be unmanaged and abated vial being continues to be utilized although it has been established already that using abated vital being as sanction not only is not a deterrent but increases abated vital being from other causes, increases detrimental behavior, increases accidents, but, maintains the facade of Mens Rea or individual causality for outcomes.

The façade of Mens Rea obfuscates the fact that since before birth, Humans are allowed to deteriorate, become impaired, become acculturated to, and become compelled into exhibiting precisely those outcomes that systems require to maintain the status quo. Pervasively such outcomes and behavior do not exist in nature, clearly exhibiting that is systems themselves causing such outcomes. Covid is not having its causal nuances treated because doing so challenges all of the factors that supply outdated, inaccurate, exploitative nuances of systems and assures that systems prioritize themselves over Humanity. There is nothing observable or able to occur in civilization that is not most accurately caused by civilization itself. Only Human priority is the product of Humanity. The status quo does not allow divulging to populations that their inclinations are manufactured, their conditions are allowed to deteriorate, and their value is to the universes transcending the circumstance which civilization and systems of the biome impose upon them. Understanding and managing this core of factors would make people use their resources, creativity, production of legislation and services prioritize themselves, and humans over systems. However, such understanding and production of outcomes and the elasticity of the mind, opinion and systems required to continue to be consistent with such understanding, may be among the strongest and most consistent priorities which have shaped this nation and the incipient design of its systems.

However, such understanding and production of outcomes and the elasticity of the mind, opinion and systems required to continue to be consistent with such understanding, may be among the strongest and most consistent priorities which have shaped this nation and the incipient design of its systems. Systems of Western Nations, this Nation and perhaps the World, were meant to be moved by information, data, understanding and improved nuances of conscious Human priority.

B. Beginning of Guidance.

Complimentary Therapy for Microbial, SARS, Corona and Influenza Affliction

The pandemic of 2020 presents the requirement for focused Guerrilla Healthcare Teams deployed as special ops teams that focus on the empirical causes of disease and detrimental behavior, including the required empirical factors for any pandemic or epidemic level pathogen.

It is recommended to enroll all Humans in health services coverage plans because merely being covered results in improved Human outcomes and decreases susceptibility. It is also recommended to proactively manage Homocysteine to below 6 Micromoles per liter in all Human populations, particularly including the prophylaxis routines described here.

Managing these factors deactivate a spectrum of required molecular factors utilized for this virus, any virus and almost all pathology, which require inhibition, impairment or polymorphism of the essential Human Developmental, defense, and regeneration enzyme known as PEMT1/2/3 and its production of defense, regeneration, repair, anticarcinogenic, antimicrobial, trypsin/thrombolytic, organic to inorganic phase transfer and embryonic plasticity enabling molecules, capabilities and pathways.

S-nitroso-N-acetylpenicillamine (SNAP) is nitric oxide donor and nitric oxide donors diminish the pathology of Corona Virus.

A refreshing blended drink, capsule coctail or prepared parenteral as well as powder for topical application near afflicted areas, capable with the following factors should ameliorate the detrimental capability of Corona Virus. Product 1 Aggregate or both Product 2 Essential and Product 3 Supplemental are therapeutically requisite. Product 4 Assistive, enables more complete regeneration of anatomy.

Supplement 0, Microbial and Viral Assistive Therapeutic

Price this as a 31, 63 and 96 serving supplement. Price as Flavored Powder. Price as nonflavored Powder for Topical Application.

(Dimethylacetothetin was not obtainable by supplier)

(Tetrahydrobiopterin or BH4 was not obtainable by supplier)

250 mg of Curcumin

250 mg of Grapeseed Extract

Berberine 200 mg

Feverfew 40 mg

Hyaluronic Acid 25 mg                    25 mg

Salvia Miltiorrhiza, Red Sage or Danshen, 100 mg

Tanshinone 10 mg

Tanshinone II 10 mg

Salvionic Acid 10 mg

Melotonin 1 mg

100 mg of Dimethyl Sulfoxide

Potassium 75 mg

Choline 800 mg.

S-Methylmethionine Sulfonium 800 mg

Trimethylglycine 400 mg

6s 5678 Tetrahydrofolate 200 Micrograms

Glutathione 300 mg

Cystathionine 100 mg

Methylsulfonyl Methane 250 mg

L-arginine 200 mg

Selenium 100 micrograms

NAD+ 30 mg

NADH 5 mg

Pregnenolone 50 mg

B12 Methylcobalamin 50 Micrograms

B6 10 mg

Iron 10 mg

Zinc 15 mg

Molybdenum 150 micrograms

30 mg Magnesium

30 mg Magnesium Citrate

5 milligrams of Citrate

75 mg Superoxide Dismutase

75 mg Catalase

75 mg N Acetyl L Cysteine

25 mg of Citric Acid

250 mg of Grapeseed Extract

100 mg of Citrulline

100 mg of Ornithine

30 mg of Histidine

30 mg of Cysteine

Docosahexaenoic Acid 25 mg

Lysophosphatidylcholine 25 mg

Linoleic Acid, omega6    5 mg

Eicospentaenoic Acid Omega3 15 mg

Vitamin A 400 Micrograms

Vitamin E 2 Micrograms

Iodine 25 micrograms

Vanadium 1 mg

Phosphorus 100 mg

1. Aggregate Essential and Supplemental Product, Therapeutic.

Price this as a 31, 63 and 96 serving supplement. Price as Flavored Powder. Price as nonflavored Powder for Topical Application.

(Dimethylacetothetin was not obtainable by supplier)

(Tetrahydrobiopterin or BH4 was not obtainable by supplier)

100 mg of Dimethyl Sulfoxide

Potassium 75 mg

Choline 800 mg.

S-Methylmethionine Sulfonium 800 mg

Trimethylglycine 400 mg

6s 5678 Tetrahydrofolate 200 Micrograms

Glutathione 300 mg

Cystathionine 100 mg

Methylsulfonyl Methane 250 mg

L-arginine 200 mg

Selenium 100 micrograms

NAD+ 30 mg

NADH 5 mg

Cobalamin 25 Micrograms

Pregnenolone 50 mg

B12 Methylcobalamin 200 Micrograms

B6 10 mg

Niacin 10 mg

Iron 10 mg

Zinc 15 mg

Vanadium 2 mg

Molybdenum 150 micrograms

30 mg Magnesium

75 mg Superoxide Dismutase

75 mg Catalase

75 mg N Acetyl L Cysteine

25 mg of Citric Acid

250 mg of Grapeseed Extract

300 mg of mixed RNA Nucleotides

300 mg of Mixed DNA Nucleotides

5 mg of Ribose

100 mg of Citrulline

100 mg of Ornithine

30 mg of Histidine

30 mg of Cysteine

Docosahexaenoic Acid 25 mg

Lysophosphatidylcholine 25 mg

Linoleic Acid, omega6    5 mg

Eicospentaenoic Acid Omega3 15 mg

Mead, Oleic, Nervonic, Elaidic, Hypogeic, Erucic, Ximenic,or Gondoic Acid 5 mg

Vitamin D as Cholecalciferol 5 Micrograms

Vitamin D as Ergocalciferol 5 Micrograms

Vitamin C 30 mg

Vitamin A 400 Micrograms

Vitamin E 2 Micrograms

Biotin 15 micrograms

Pantothenic Acid 3 mg

Calcium as Calcium phosphate 50 mg

Iodine 25 micrograms

Vanadium 1 mg

Phosphorus 100 mg

250 mg of Curcumin

250 mg of Grapeseed Extract

50 mg of Ribose

Berberine 200 mg

Feverfew 40 mg

Hyaluronic Acid 25 mg

Docosahexaenoic Acid 25 mg

Pink Himalayan Sea Salt 1 mg or lowest mg otherwise possible.

Ceramide                      25 mg

Salvia Miltiorrhiza, Red Sage or Danshen, 100 mg

Tanshinone 10 mg

Tanshinone II 10 mg

Salvionic Acid 10 mg

2. Essential Product Number 2.

Here is the separate Essential Product that does not have factors in the supplemental product list.

Price this as a 31, 63 and 96 serving supplement. Price as Flavored Powder. Price as nonflavored Powder for Topical Application.

Potassium 75 mg

Choline 800 mg.

S-Methylmethionine Sulfonium 800 mg

Trimethylglycine 400 mg

6s 5678 Tetrahydrofolate 200 Micrograms

Glutathione 300 mg

Cystathionine 100 mg

Methylsulfonyl Methane 250 mg

L-arginine 200 mg

Selenium 100 micrograms

NAD+ 30 mg

NADH 5 mg

Cobalamin 25 Micrograms

Pregnenolone 50 mg

B12 Methylcobalamin 200 Micrograms

B6 10 mg

Niacin 10 mg

Iron 10 mg

Zinc 15 mg

Vanadium 2 mg

Molybdenum 150 micrograms

30 mg Magnesium

75 mg Superoxide Dismutase

75 mg Catalase

75 mg N Acetyl L Cysteine

25 mg of Citric Acid

250 mg of Grapeseed Extract

300 mg of mixed RNA Nucleotides

300 mg of Mixed DNA Nucleotides

50 mg of Ribose

100 mg of Citrulline

100 mg of Ornithine

30 mg of Histidine

30 mg of Cysteine

Docosahexaenoic Acid 25 mg

Lysophosphatidylcholine 25 mg

Linoleic Acid, omega6    5 mg

Eicospentaenoic Acid Omega3 15 mg

Mead, Oleic, Nervonic, Elaidic, Hypogeic, Erucic, Ximenic,or Gondoic Acid 5 mg

Vitamin D as Cholecalciferol 5 Micrograms

Vitamin D as Ergocalciferol 5 Micrograms

Vitamin C 30 mg

Vitamin A 400 Micrograms

Vitamin E 2 Micrograms

Biotin 15 micrograms

Pantothenic Acid 3 mg

Calcium as Calcium phosphate 50 mg

Iodine 25 micrograms

Vanadium 1 mg

Phosphorus 100 mg

3. Supplemental Product Number 3

Here is the product with factors not exhibited in physiology, although a few of these are and seemed useful to separate because of their utility.

Supplemental Product

Price this as a 31, 63 and 96 serving supplement. Price as Flavored Powder. Price as nonflavored Powder for Topical Application.

250 mg of Curcumin

250 mg of Grapeseed Extract

50 mg of Ribose

Berberine 200 mg

Feverfew 40 mg

Hyaluronic Acid 25 mg

Docosahexaenoic Acid 25 mg

Pink Himalayan Sea Salt 1 mg or lowest mg otherwise possible.

Ceramide                      25 mg

Salvia Miltiorrhiza, Red Sage or Danshen, 100 mg

Tanshinone 10 mg

Tanshinone II 10 mg

Salvionic Acid 10 mg

4. Assistive Product Number 4

Price this as a 31, 63 and 96 serving supplement. Price as Flavored Powder. Price as nonflavored Powder for Topical Application.

If you do not have any of these products, just omit them and do not include these in the product that is an aggregate of all of the supplements because it may be nonvegan compatable and nonvegetarian.

25 mg Wheat Germ, defatted if possible

25 mg of White Kidney Bean Powder

Melotonin 1 mg

500 mg of Bone Powder Bovine or other. If multiple versions of Bone powder available, then use all available making up 500 MG

500 mg of Bovine or Other Glandular made of all available anatomical parts including heart, kidney, lungs, bone, collagen, hepatic, glands, or other. If Other sources or Organisms glandular available, then mix organisms to make up 500 mg.

150 mg of Collagen, Bovine or other. If multiple organisms, then mix thee to make 150 MG of all collagen types.

50 mg of Flax Hull Lignans

50 mg of Beet Root Powder from Beta Vulgaris

50 mg of Golden Flax Seed Powder

25 Citrus Bioflavonoid

150 mg of Red Superfood

150 mg of Green Superfood

200 mg of Mixed Amino Acids except for Phenylalanine

15 mg of Alanine for antiallergy

15 mg of Histidine for antiallergy

1 mg Niacinimide

15 mg of glutamine for antiallergy

Managing these factors deactivate a spectrum of required molecular factors utilized for this virus, any virus and almost all pathology, which require inhibition, impairment or polymorphism of the essential Human Developmental, defense, and regeneration enzyme known as PEMT1/2/3 and its production of defense, regeneration, repair, anticarcinogenic, antimicrobial, trypsin/thrombolytic, organic to inorganic phase transfer and embryonic plasticity enabling molecules, capabilities and pathways. Viruses, pervasively, are opportunistic pathogens, requiring or producing the inhibition of the enzyme PEMT through the exhibition of Inducible Nitric Oxide Synthase, although energy fields, choline deficiency, disease, homocysteine above 6 micromoles per liter, chlorine, fluorine, and medicines, as well as injury and impairment, emotional destabilization, behavioral health conditions, and distress, all can result in inhibition of PEMT in numerous ways including iNOS. Restricting movement physicially or spatially of mammals, including developing Humans being 'swaddled', and including restricted movement otherwise, result in expression of iNOS, presumably because PEMT inhibition results in increased Homocysteine which causes subjectivity, suggestability and susceptibility to physiological, perceptive, cognitive, and behavioral influences that would lead to finding Choline and nutrient rich foods, such that iNOS is expressed to counteract massive apoptosis in tissues resultant of choline inadequacy and PEMT inhibition by increasing the turgor of cellular entities as they decrease in number per micrometer tissue resultant of such massive apoptosis as well as to enable strengthening of choline and PEMT inadequate cellular entities which pause in the Mitotic Cycle at Hypertrophic phases. Similarly, the exhibition of exposure and production of Immunoglobin and Monocytes that are response to a pathogen or pathogenic factor does not assure immunity against additional exposure to the pathogen. Choline deficiency and PEMT inhibition both result in deterioration or involution Thymus, Hepatic tissue, Splenic tissues, Renal Tissues and other areas of Splanchnic systems, some of which regenerate themselves because of PEMT function, as well as causes constriction of the Caveolae in which much of Immunological antigen presentation, receptor activity, secretion, signal transduction, and cellular communication occur. The promote Cholesterol Receptors as important pathays for Viral entry into the plasma membrane interstitial space, although Phospholipase D and iNOS enable escape of Viruses from this Toxic Interstitial Space. Involution of these tissues, including deterioration of Lymphatic tissues result of Choline inadequacy, inhibited PEMT, and impaired VLDL delivery to Lymphatic Tissues, impairs response even for an already primed and memorized adaptive immunological response as well as impairs innate and compliments immunological function, such that choline deficiency and Homocysteine both describe age correlated susceptibility resistant Nosocomial Microbial Affliction as well as susceptibility to chronic microbial affliction and increased adverse outcomes which can be correlated to phase of being or age. Microbes or viruses can also move from genotype to genotype and from environmental phenotype to phenotype, during the course of disease and during the course of movement through a medium such as through populations that are not able to prevent affliction cycles systemically and systematically.

1. Choline/Sulfur/Methylation/Hydride Deficiency, al of which are inhibitors of PEMT. 2. Electrical and Communications energy exposure which inhibit PEMT through iNOS and enables viral escape from toxic Plasma Membrane interstitial Space through Phospholipase D activity. 3. Inhibitors of the enzyme PEMT which every Pathogen and Disease inhibits with priority. 4. Inducible Nitric Oxide Synthase, an inhibitor of PEMT. Uncoupled Nitric Oxide Synthases, Superoxide, H2O2, Peroxynitrite, Hypochlorite and the empirical cause of Stroke and Sudden Adverse Health events known as TrimethylamineNOxide, all of which inhibit PEMT. AP1, an inhibitor PEMT and upregulator of Histamine/Xenobiotic/Inflammatory CDP Choline Pathway. SP1 which performs similarly as AP1. C - Reactive Protein an inhibitor of PEMT. Indoleamine 2,3 Dioxygenase, an inhibitor of PEMT. Thrombin, an inhibitor of PEMT. Methylglyoxal, a primary active factor in sepsis, inhibitor of PEMT and potentiator of D Lactate/Lactic Acid and L Lactate/Lactic Acid. D Lactate/Lactic Acid and L Lactate/Lactic Acid. Hyperoxularia. NAD+ depletion and NADH Depletion, all of which inhibit PEMT and upregulate Homocysteine. PCKS9 inhibitors may increase Susceptibility and cause increase detrimental outcomes with regard to Viral Pathology Generally. Chloroquine seems to enhance iNOS while Hydroxychloroquine is presented in the literature as inhibiting iNOS, although there is no information on how these factors affect Homocysteine, so Homocysteine has to be aggressively managed if using Hydroxychloroquine.

The H5N1 influenza virus is known to have increased iNOS exhibition in tissues correlative to level impairment or level of virulance. Resource. 10.1371/journal.pone.0014561.

ASFV viral activity inhibits iNOS, but its way of doing this inhibits iNOS resultant of Lipopolysaccharide and basal iNOS gene transcription activity in Macrophages, suggesting clearly the paradox of iNOS being pathogenic to viral vectors, buts its prolonged expression being detrimental enough to enable susceptibilities. Viral vectors may have different precise modalities of beginning, concluding and persisting pathology, iNOS seems to be an essential feature commandeered by viral vectors to their own specific modalities of pathology. Often, however, studies observing that iNOS is detrimental to viral pathology progression may mistake ephemeral iNOS activity and progression deterioration of all iNOS activity as a result by observing only iNOS activity against viruses before deterioration of Ca2+, L-Arginine, Plasma Membrane, Endoplasmic Reticulum, Sarcolemma sheathing and cellular shape, as well as before eNOS/nNOS inhibition, Caveolae constriction, impaired immune function, and uncoupling of iNOS/nNOS/eNOS to produce reactive oxygen and reactive nitrogen species that become Superoxide, H2O2, Peroxynitrite, Hypochlorite and TrimethylamineNOxide, essential components to an infarct. Similarly, the way in which iNOS expression for extended duration impairs immunology and metabolism may be differentially required for Macrophages compared to other cellular entities, as well as may be differentiated in its effect after pathology has emerged or after affliction occurs at the cellular level. Resource. J Virol. 2006 Nov;80(21):10487-96.

The ability of ASFV to inhibit iNOS may not be unique, since the inhibition of NF kB also occurs along with inhibition of a pervasive other Immunological factors such as MHC Class presentation and others. This presents the potential that inhibition of iNOS may be different in viral vectors affecting nonhuman organisms. This also presents that iNOS expression may not be intricately and specifically experimentally explored in nonHuman viruses. Also potentiated is the fact that ASFV inhibition of iNOS may not be unique at all because the pathology pattern for viruses includes impairment of iNOS either constitutively or through causing it to become depleted of metabolites and become uncoupled, as well as deterioration of iNOS activation and deterioration of eNOS/nNOS activation because these cause exhibition of toxic reactive molecular species. Similarly, it is possible that incipient cellular level pathology requires iNOS for viral vectors to enter the cytoplasm without being deteriorated after extended duration of exhibition of iNOS has produced the susceptible cellular phenotype. Regardless, iNOS expression for extended duration continues as an essential factor in viral pathology for Homo Sapiens and may be an essential factor for viral pathology in nonHuman organisms also. It may be necessary to ascertain if through iNOS, ASFV inhibits iNOS, as it does not seem to utilize at least after viral affliction occurs. However, certainly through C Reactive Protein and Thrombin as the literature presents, as well as potential through other mechanisms, ASFV does inhibit PEMT regardless of if ASFV using iNOS to inhibit PEMT after before affliction or after affliction. Each disease may have to be analyzed to see which if the major 10 or 15 different factors essential to disease are correlated or are required, followed then be management of the applicable factors. Thrombocytopenia exhibited with ASFV Viral Vector suggest that either PEMT is inhibited or its pathway factors are inhibited because PEMT inhibits Leukocyte availability and promotes Erythrocyte Production. Prothrombin time is only marginally changed by ASFV but thrombin time is increased substantially. Activated partial thromboplastin, 1 stage, and thrombin coagulation time al were increased by ASFV, in experimental observation. Resource. 10.1371/journal.pone.0223955

However, nitric oxide donors such as S-nitroso-N-acetylpenicillamine (SNAP) were found to have antiviral activity for Corona Virus. 10.1016/j.ijid.2004.04.012.

The literature observes in some instances that NOS2 or iNOS inhibition does not prevent demyelination in Corona Virus affliction, but Nitric Oxide inhibits Corona Virus, suggesting that the experimental observation of iNOS with regard to demyelination including use of nonselect of inhibitor of iNOS that also affected eNOS/nNOS or the demyelination occurring with iNOS in the experimental observation did not activate the pathways that would regenerate Myelin, as well as may have omitted the consideration of iNOS expression of Choline deficiency, energy fields, and Lipopolysaccharide. Resource. 10.1128/JVI.74.16.7683-7686.2000 Resource. 10.1128/JVI.79.3.1966-1969.2005

Another study observes an increase in Reactive Oxygen and Reactive Nitrogen Species occurring in direct correlation with iNOS production, using experimental usage of LN MMA. The study occurred in experimental conditions using lung tissues affected by Influenza. Resource. 10.1046/j.1365-2567.2000.00142.x

NOS2a Gene Haplotype is correlated with Limited duration of HPC Hepatitis C pathology and is associated with less substantial Dengue Viral Affliction. 10.1186/1471-2334-5-64

Melatonin at 20 mg per kg of anatomical mass to 60 mg per kg of Anatomical mass inhibits iNOS and Lipid Peroxidation in experimental small nonhuman models of Lipopolysaccharide induced iNOS expression and microbial affliction of Pulmonary and Hepatic tissue, specifically disrupting the cycle of multiple organ distress syndrome and Pulmonary distress syndrome observe in models of Corona, Influenza and other viral affliction. The inhibition of iNOS and Lipid Peroxidation occurred through inhibition of iNOS gene transcription, while also linking iNOS clearly to cascade of Uncoupling of Nitric Oxide Synthase, uNOS, and linking iNOS and uNOS to Superoxide, H2O2, Peroxynitrite, Hypochlorite and Peroxidation of Lipids. Melatonin counteracted canonical Endotoxemia features including alleviating increases in Aspartate, Alanine, Aminotransferases which have to be increased to assist in managing detoxification as well as enable Methylation pathway supply of Trimethylsulfonium/Trimethylselenium/Trimethyltellurium/Methyl Factors, as well as alleviated increases in Alkaline Phosphatase, Creatinine, Urea, Uric Acid, and iNOS RNA, all clearly presenting the Melatonin protects Pulmonary, Hepatic, and Renal tissues to disrupt septicemia, endotoxemia, and multiple organ system deterioration associated with less than optimal outcomes. 65 Percent decrease in iNOS expression occurred with 60 mg per kg of anatomical mass instrumentation of Melatonin. Curcumin inhibits iNOS both at the transcription level and through increasing the deterioration of iNOS enzymes after transcription while Curcumin and its major metabolites also inhibit ERK 1/2. Another study clearly establishes that Curcumin inhibits small nonhuman mammary gland iNOS expression resultant of Lipopolysaccharide, Lipopolysaccharide increases iNOS by 2000 percent, increase in iNOS was accompanied by deactivation of eNOS which clearly confirms the depletion of L-arginine and Ca2+ by INOS as a deactivator of eNOS/nNOS, Curcumin scavenged Nitric Oxide Radicals such as Peroxynitrite, and after Lipopolysaccharide was removed, curcumin did not diminish intermittent upregulation of iNOS presumably in its biologically intended role to flush microbes from Cytoplasm, supply reactive molecules to the plasma membrane interstitial space and help enabled strength of cellular entities during massive cellular lysis, apoptosis, and necrosis from injury, immunological function, and choline inadequacy. The protective effect of curcumin against inflammation, oxidation, microbes, neurological deterioration, colon pathology, neoplasm, and mutations of genetic material were attributed to its preventing of NF kB from being translocated from the cytoplasm generally or Cytosol into the Nucleus requiring iNOS to be expressed from very specific pathways instead of allowing iNOS from being expressed as a general inflammatory response commandeerable by pathogens and pathogenic processes. Resource. FASEB J. 1999. Sep; 13(12):1537 to 46. Resource. 10.1016/j.intimp.2010.11.013. INT Immunopharmacol. 2011. Feb; 11(2);179-86. Resource. Nitric Oxide. 2000. OCt; 4(5):505 to 515. Resource. 10.3892/mmr.2014/3079.

This article presents understanding and therapeutics which could be utilized to prevent and manage Corona Virus and SARS for probably less than 1 dollar per patient per day once mass production of the capabilities has occurred. The complexity is that preventing or managing the factors that enable CORONA and SARS would also, with duration, result in the alleviation and prevention of all Human disease, including pathology associated with age and include factors integral to less than optimal behavioral outcomes. These analysis present that since 1878 a prominent modality of accomplishing the same has been known and unimplemented. These analysis presented that such omitting of essential capability has resulted in hundreds of millions of unnecessary instances of abated vital being individually in countries around the world, with billions of unnecessary instances of abated vital being and detrimental behavioral outcomes occurring otherwise. Furthermore, these analysis observe that pervasively since 1878, the detrimental events and massive detrimental Human outcomes which may have occurred, all have occurred because of the emergence of information and information systems which are eluting into Human consciousness these omitted capabilities and their clinical/molecular nuances, all which have produced perturbations in the Human experience as alternative outcomes compete for prevalence over influence to how the status quo in civilizations of the world is exhibited. Similarly to all great data science discoveries, the human experience in this regard requires a narrative, and this narrative for what has occurred since 1878 as well as what might have occurred since 1878 if Human priority had its druthers, is something that every substantial human event seems to strongly visualize, ideate, provide insight for, and elute derivatives for how Humanity might avoid repeating similar subverting of Human priority at any other nuance of the Human Experience.

Fortunately, the use of analytics, research, genomic data and metabolome analyses as well as proteomics, all have changed the production of therapeutics from being merely understanding how to amplify the factors produced by physiology without enhancing physiological ability to do increase such factors constitutively. Todays therapeutics, beginning in the 1960s or earlier, have been founded upon precision molecular and metabolic pathway elucidation, pathogen protein and genetic as well as transcriptional pathway understanding, quantum influences including Atom level, Hydridic and other research, as well as determining the precise quantum, Atom level, Molecular, Metabolic, Genetic, Proteomic, Enzymic, and translative processes or structure, such as pockets, unlocking loci, activation, deactivation, deterioration, and synthesis of factors in every disease, every behavior, every physiological, metabolic, and other outcomes observed in the spectrum of Human outcomes. CRISPR Capabilities alone, has the potential to specifically find and repair every genetic anomaly as well as specifically disable every microbe, bacterium and virus ever exhibited. Transduction Domain Synthesis allows Macromolecular computers used in computational proteomics to process the conditions in every cellular entity and walk each cellular entity individually along its own path to optimal cellular function. However, the fundamentals include assuring the function of PEMT because PEMT's diverse enablement of development, regeneration, stability, control, health and social behavior, reflects the incipient favor differentially afforded to Humanity by the favor among the Universes required for Humanity to emerge and persist.

The data suggests that this epidemic may have emerged upon the the obscure and esoteric interaction between derivatives of systems which observe, presented, and manage detrimental outcomes at systemic levels. A review of the clinical data suggests that regional entities of nations which practice use of abated vital being as a sanction are not correlated with increased pathology, as they may often be during such crises, unless one considers the status of such regional entities with regard to using abated vital being as sanction is considered. Indeed, if one considers the position of regional entities before 2000, there is a reasonable correlation to level afflicted population and levels of abated vital being correlative to utilization of abated vital being as a sanction.

Because much of the information in health services research and development clearly lead to the conclusions present here and every disease should have stopped being exhibited in 1878, much of the information presented in systems which is not consistent with this conclusion merely present the opinion and perspectives that are skewed toward priorities of systems over the priority of Humanity. Anytime empirical analyses clearly showing the causal linkages to disease and how to prevent detrimental Human outcomes tangentially becomes removed or made to be more obscure, as well as when decisions which have enabled priority of Humanity become changed or superseded by other decisions or social constructs that have less Human priority, a reset, adjustment, or adjudicative interaction occurs at quantum, social, physiological, behavioral and system levels in which alternative outcomes become to compete for prevalent influence to the status quo. Human inadequacy at molecular, metabolic, physiological, behavioral, economic, social, shelter, Home or residential status, Genetic, health status and other levels become the control points by which such competitive interacts cause change, promoting deterministic influence to the status quo, deteriorating prevalent influence to the status quo and endeavoring to attain or continue determination priority in shaping outcomes among civilizations, groups, and individuals.

What is now known is that the more encompassing and integrative systems are into Human physiology, perceptions, cognition and behavior, the more these replace their own priorities in human inclination, decision making, physiology and behavior supplantingly of the conditioning, perception, cognition, rewards systems function, suprachiasmic nucleus function, associations and behavior which would keep humans prioritizing obtaining of choline, methylation, hydride, other nutrients, and empirical nuances of Human sustainment that are all impaired by allowed Human inadequacy. Pervasively, systems replace Human inclination to find Hydride, Methyl Groups, Choline, Choline Pathway factors, Nutrients, Food/Shelter/Social/water security, and other factors using the same colors, shapes, smells, correlations and associations that would lead to these essential factors in nature, such that Humans are potentiated toward those outcomes which systems benefit from instead. Similarly, the patterns in any pathology are as programmable as software in Humans causing humans to be more susceptible than the would be otherwise to affliction and guiding Human outcomes in thousands of subtle reinforcing ways to the physiological and behavioral outcomes described by, expected by and benefit from by systems.

Removing these encompassing influences by removing personal information from internet systems, inhibiting energy and communications fields, covering power outlets, becoming aware of how such influences determine about 90 percent or more consumer behavior and thus influence at least 90 percent of human behavior otherwise, all provide a way managing beneficently the social transformation of disease toward the beneficent Human priorities that are the incipient impetus for the social transformation of medicine, Humanity and Human outcomes.

Moreover, in 2019, a particular Western Nation, known for its prioritization of Civil Liberties and Human Rights, continued its utilization of Abated Vital Being as a Sanction, and such decision is timely and has correlations with exhibition not only to levels of pathology for other disease, not only has correlation with air travel incidents which emerged as very public focusing event regarding air travel in early 2020, but also has correlation with emerging of this pandemic. The compendium of research associated with this article clearly observes that in the years in which this particular Western Nation founded upon the constructs of Liberty produced a moratorium on the Utilization of Abated Vital Being as a Sanction in 1972 to 1976, rates of abated vital being around the world resultant of any causality and air travel accidents, all decrease in substantial ways, with a 1 percent decrease in abated vital being and a 75 percent decrease in air travel accidents. It is very likely that because such Western Nation's foundational symbols and systems mimic PEMT function, and mimic expression of the genes within the PEMT gene expression pattern, at least translatively in their benefit to Humans and Civilizations socially, it is possible that such benefit becomes mitigated when systems of such nations make decisions that are anathema to Human Priority.

The telling question is, how does a universe full of microbes, and a biome with organisms or biological factors pervasively, suddenly change to become highly pathogenic in a way that would possibly be so virulent to the its host system that it becomes self limiting? Essentially, viral epidemics limit their own duration of exhibition through increased pathogenic nature such that any microbial or pathology otherwise, particularly those which are most detrimental, are required to eventually become less potent in order to sustain themselves, often becoming endemic to populations and even becoming hidden in large expanses of unused Human DNA. The answer largely includes that the causes of disease are treated adequately and synthetic factors such as synthetic energy and other fields, striates that can be included in table salt, chlorine in water, fluorine in water, allowed choline deficiency, and the way in which Homocysteine and iNOS are pervasively upregulated by these factors as well as may be pervasively upregulated even by therapeutics or Pharmaceutical capabilities. This nuances of the status quo were inherited by generations now in existence, suggesting that there should be less inertia and impedance to making these systems better.

  

Diseases do not exist, but are progressive resultant symptoms of incipient, foundational causal factors that must change the molecular basis of biological function which are able to be diagnostically ascertained at their most incipient and empirical causal levels. Pervasively, causal mechanisms as mistakenly presented at less than empirical levels or only observed as the outcomes which are known inaccurately as disease or at observable levels such as changes to biological function and tangible nuances of disease. The reason that diseases have persisted since ancient times and since 1878 are that less than empirical therapies or interventions relieve the phantoms of observable change and tangible nuances of disease without managing incipient and empirical causalities. Resultantly, merely changing habits, location, nutrition, or the way that energy, magnetic, environmental, or other influences converge in a particular health consumer results in the same incipient causalities emerging as behavior, other conditions, averse health status or sudden adverse health events as well as potentially sudden adverse behavior. Particularly, prevention, beneficence and due diligence as well as requisite transparency in care processes, require explaining to health consumers and practitioners how these incipient causal factors are the empirical causal factors of impaired decision making, disease, behavioral health statuses, adverse behavior, adverse health statuses, sudden adverse health events, or sudden averse behavior, as well as unsuccessful therapeutics, behavior modification, biomedical interventions, as well as complications, all result in detrimentally sustainable supply of unfortunate Human outcomes.

A most interesting understanding emerges from reviewing pandemics through the history of the Human experience, or known history of the Human Experience. Early epidemics were often bacterial, parasitic, or particularly when viral, were all limiting of themselves because the transmittal mechanisms were an organism with limited habitat, an organisms that could be ascertain tangibly, an organisms that was not mobile enough to sustain widespread affliction, were of such detriment that these limited the ability for Humans to conduct widespread disperal of the pathogen. It is clear that the pandemic with widespread affliction emerged along with the control of environmental conditions in transportation capabilities and dwellings which enabled carriers as well as pathogens themselves to withstand limiting conditions of the changing seasons, seasonal improvement in organism immunological function, and natural changes to practices and learning which occur when such affliction may be endemic or characteristics within a local context. Importantly, directly correlative to the emergence of Electricity in the Western World, pandemics of viral affliction also emerged with Influenza in the 1870s and 1880s, and of course, the 1918 influenza. Thus artificial light, electrical fields, communications fields and their ability stimulate iNOS, Phospholipase, DNA impairment and other inflammation enabled or occurred in correlation to the gradual replacement of Choline Inadequacy as the primary progressive cause of detrimental Human physiological and behavior outcomes supplantingly for diseases resultant of Striates in Table Salt, Chlorine, Fluorine, iNOS from sources other than Choline deficiency, Phospholipase D, DNA impairment, and Diabetic pathology all of which characterize prevalence of Lymphoma, Leukemia, Oncology, Diabetes, Detrimental Behavior, Chronic disease, genetic diseases, Cardiovascular diseases, and other pathologies as well as directing of such influences toward behavioral health conditions, behavior, and even the most detrimental of behaviors. Pervasively, the swelling of Endothelial areas of Anatomy, readying of Nitric Oxide Synthases for uncoupling resultant of iNOS depletion of L-Arginine and Ca2+, impairing of Myelin Basic Protein availability from inadequate L-Arginine, as well depletion of Ca2+, Collapsing of the Sarcolemma, systemic gradients of Ca2+ depleted from bone and marrow, causing of cellular entities to have amoeba shape, and inhibition of PEMT, all may hasten, cause, potentiate or are constitutive of how Choline inadequacy, S-Adenosyl Homocysteine, Homocysteine and TrimethylamineNOxide, as well as iNOS and uNOS and other factors presented here result in detrimental Human outcomes. Many of these factors are required by every disease, including microbial and viral conditions. Mitigating the influence of artificial energy would be substantially inexpensive integrative nuances of product, services and infrastructure design, production, development, implementation and Maintenance. Even in the emergency department, intensive care, inpatient, outpatient, extended duration or other care nuances, these factors are not adequately managed, omitting essential advantageous benefits that are the difference between outcomes that optimal and less than optimal outcomes. The omitting of these factors suggests that Humans are being less than consciously, consciously, systemically, and systemically compelled or beguiled to act against their own self interest and the interests of Humanity.

Resources. "20 of the worst epidemics and pandemics in history." Life Science. Twenty First of March, 2020.

Such explanation to and understanding by Health Consumers and Clinicians enables systemic progression from unconscious incompetence in which systems shape these outcomes into the Human outcomes it requires for quotas, the status quo and to achieve objectives which do not have to exhibit Human priority, progressively toward conscious incompetence in which Humans become aware of what they do not know, toward unconscious competence in which the semblance of conscious control over health status and behavior emerges, to the exhibition of conscious competence when Humans are consciously aware of how systems continuously impose influence that can displace intrinsic Human motivation with their own influence and priorities that challenge priority of self, challenge self control, and potentiate the less than optimal Human outcomes as well as optimal Human outcomes which systems expect, require and obtain benefit from.

Imperatively, if a epidemic does not invert or change the Gompertz Sigmoid distribution or Curve of abated vital being occurrences, then it typically exhibits the same modalities of detriment which are already known, particularly the list of diagnostic factors present here, but more completely presented in the artifacts presented in the profile attached to this posting of information. These include inadequate Choline, Methyl Groups and Hydride, subsequent impairment/inhibition of PEMT, upregulation of S-Adenosyl Homocysteine, Homocysteine and Homocysteic Acid, along with increased levels of TrimethylamineNOxide, AP1, SP1, Thrombin, Indoleamine 2,3 Dioxygenase, iNOS, Uncoupled Nitric Oxide Synthases, C Reactive Protein, Superoxide, H2O2, Peroxynitrite, Hypochlorite, Hyperoxaluria, Methylglyoxal, inadequate NAD+/NADH, L-Lactic Acid, D-Lactic Acid, indequacies of sulfur, S-Methylmethionine Sulfonium, Methylsulfonium, Trimethylglycine, Glutathione, Peroxyredoxin-6, Methanethiol, Dimethylacetothetin, Trimethylsulfonium, Folate, 6s 5678 Tetrahydrofolate, Iron, L-Arginine, Zinc, Vanadium, B12, B6, Niacin, Biotin, Thiamine, Riboflavin, Pantothenic Acid, and cobalamin. Managing these inadequacies obliterates 99.99999 percent of the potential for impaired, less than optimal, complicated health and behavioral outcomes almost without regard to what causalities may have incipiently or proximately been cursorily considered to be causal.

Although inhibition of Choline Kinase alpha is pervasively therapeutic in pervasive nuances of pathology involving differentiated cellular function, clinicians must be careful to closely observe utilization or not utilize Choline Kinase inhibitors because these disrupt the CDP Choline Pathway that supplies Cytidylyl Metabolites and CDP Choline, as well as upregulate the essential inflammatory protective response occurring in Pulmonary tissues and other tissues. Choline Kinase Alpha is required during several Gestational phases and is required at birth to produce a rapid adaptive Histamine, xenobiotic and allergic response that is essential to rapid Pulmonary System activation after emerging from the Gestational Environment into the Atmospheric Environment. However, there may be substantial benefit obtained when the Inflammatory, Xenobiotic and Histamine response is overly active as it may be in Pulmonary Inflammation Syndromes.

Chloroquine and Hydroxychloroquine are presented as prospective therapeutics for Coronavirus. Regardless of the utility of these factors, Chloroquine causes the expression of iNOS and, however, Hydroxychloroquine inhibits iNOS at least in particular cellular entities. Hydroxychloroquine may be useful in managing pulmonary inflammation and inhibiting an essential factor in viral pathology generally, although Hydroxychloroquine is presented in the literature as inhibiting interleukin1b enabled iNOS, such that it may continue to be essential to inhibit iNOS from energy fields, other drugs, choline deficiency, or selectively inhibiting it with factors that inhibit iNOS regardless of what influence may be causing its expression. Curcumin and numerous L-Arginine analogues, as well as other capabilities are known to inhibit iNOS selectively without to regard to what pathway may be stimulating its expression. If Chloroquine is used instead of Hydroxychloroquine, a strong inhibitor of Nitric Oxide Synthase such as Hydroxychloroquine, Curcumin or pharmacological inhibitors otherwise is recommended. The literature was not conclusive with regard to Homocysteine resultant of Chloroquine or Hydroxychloroquine although studies did not observed lowered Homocysteine in therapeutic groups using these capabilities and it is typical for any therapeutic to increase Homocysteine through the detoxification pathways that include Cytochome P450, COMT, and other methylation factors.

10.1016/j.phrs.2004.10.004

Scand J Rheumatol. 2005 Nov-Dec;34(6):475-9.

10.1186/s13046-018-0938-5

10.3389/fphar.2019.01380

However, iNOS is also produced in other interleukin pathways, other pathways, from inhibition of PEMT1/2/3, energy fields and communication fields, artificial light, chlorine such as in water, fluorine such as in water, microbial or bacterial lipopolysaccharide, bona fide injury, inflammation otherwise, viruses through Macrophage activation, Macrophages through stimulation of other cellular entities, change in gravity such as when astronauts return from space, massive deterioration of cellular entity density correlated to lysis as well as necrosis and apoptosis occurring from choline deficiency as well as C reactive protein and Protein C activity along with Cellular, Humoral, Adaptive, Innate and Complements immunological function. iNOS, ephemerally exhibited, beneficially flushes the cytosol of microbes and provides Nitrogen molecular species for use within the plasma membrane interstitial space to increase the turgor of cellular entities in tissues which are depleted of adequate number of cellular entities per micrometer to prevent systemic structural collapse and disorientingly complex deterioration of numerous systems of physiology known as the syndrome M.O.D.S. The Hyperactivation of immunological systems and usage of Immunological systems to stop tissue deterioration begin near birth to manage the effects of choline deficiency and is exhibited during inflammatory syndrome such as Pulmonary Distress Syndromes associated with Microbial Pathology because without adequate Choline and DHA enriched Phosphatidylcholine derived from PEMT1, PEMT2, and PEMT3, the Immunological System must balance maintaining physiological structure with exhibiting cellular Immunological function which oppositely enable apoptosis as well as necrosis with cellular immune function compared to preventing these when maintaining physiological structure. Chloroquine, however, according to the literature, does not inhibit iNOS. Similarly, this analyses was not able to reasonably and efficiently ascertain in the data, clinical information, or literature if Hydroxychloroquine inhibits iNOS transcriptionally, Enzymically, or if it inhibits a pathway to iNOS express or if it inhibits a pathway to iNOS activation. Thus, therapeutic teaming may be optimal.

The inhibition of NF kB by ASFV would prevent the role of NF kB in preventing apoptosis, although NF kB activation may be a modality of iNOS expression or can be expressed in correlation with iNOS and Diacylglycerol increases. NF kB expression and iNOS expression may be differential factors in the paradigm of Hemorrhagic Viral Affliction compared to nonHemorrhagic Viral Affliction.

PCKS9 assists modulates endosome recycling and can promote Lipid absorption through which Viral Entry is enabled as well as through which recycling of endosomes with Virions may occur for distribution throughout physiology. Inhibiting PCKS9 in it ProPCKS9 phase before being segmented for activation and catalytic activity, may enhance susceptibility to viral activity. A study observes that PCKS9, and in another study ProPCKS9 in particular, inhibits HCV cellular entry and viral pathology in way that increases with level of PCKS9 expression, such that cellular lineages utilized for in vitro assay of HCV pathology were made resistant to HCV affliction when PCKS9 was stably expressed. Although inhibition of the CD81 and NS5A at NS5aa, as well as decreased NS5A integration into RNA, were exhibited with PCKS9 expression in way that disrupted these essential nuances of HCV cellular pathology, PCKS9 is correlated with VLDL expression, and VLDL expression is correlated with PEMT activity. These seem to be mere nuances of the diverse, powerful, commandeering of the biome and nuances of biology by the enzyme PEMT. Resource. Hepatology. 2009 Jul;50(1):17-24. doi: 10.1002/hep.22911. Resource. 10.1099/jgv.0.000987.

Similarly, amazing stories have emerged in which regeneration of limbs, appendages, aspect of anatomy, dermis, organs, tissues, have emerged in diverse organisms including mammalian experimental contexts. Amazingly, and expectedly, every one of these diverse and amazing exhibition of regeneration, repair and scarless wound healing utilize a factor that is enabled by or produced resultant of PEMT Function. The omitting of PEMT and omitting of Homocysteine as an indicator of PEMT status, along with the factors presented here, are clearly emerging as an impedance or impedance or obstacle to Human transcendence, such that all of the detrimental Human outcomes at physiological and behavioral levels emerge as a result or become exhibited as a systemic way of eluting information to Human populations such that Humanity might be guided toward the answers to such impedance.

PCKS9 inhibitors, therefore, can inhibit an essential benefit of the enzyme PEMT.

10.1099/jgv.0.000987

The large compendium of research associated with this article presents clearly that energy fields can be enhanced by the influence of paper based, list based, directory associated, and even information systems and internet based systems. Clearly, that which is most indicative of susceptibility to Corona virus includes exhibition of international travel identification, travel identification, or being resident in a system which provides care for older populations. Describing how information directories or internet based systems enhance susceptibility is merely represented by a human whom is speaking in a room full of people in a less than clearly discernable way causes Humans to look for them, find them, and then focus on them visually to enhance perception of the information being spoken. It can be described be observing the same influence which results in animals in the wild knowing when they are being viewed by a potential detrimental organism such as bird or small animal which must be aware of its environment for survival. It can be described as how your pet or animal can know when you are observing it without seeing you. Similarly, these include lists, directories or systems that include names, phone numbers, GPS location, addresses, Mac Address, Ip Addresses, and other indicators that somewhat uniquely identify location and associate people with these addresses. These merely enable focus of energy exchange, resulting in upregulation of inflammatory G Proteins and upregulation of inducible Nitric Oxide Synthase, all of which can modulate production of Sphingosine 1 Phosphate availability for inflammation for direction toward inflammatory G Proteins as well as direct Eicosanoid production or direction of S1P toward Phosphoethanolamine and Hexadecenal which have effect of pheromones and antiinflammation as well as arousal. iNOS can result swelling of endothelial areas in all aspects of physiology which increases sensitivity and results in a more rapid progression toward uncoupling of iNOS resultant of circumstance or stimuli. Sure, iNOS inhibits viral activity in the Cytoplasm but it seemed to have been intended as an ephemeral flushing mechanisms such that when exhibited for extended duration, apertures are produce in plasma membrane and endoplasmic reticulum, Ca2+ and L-arginine are depleted from inside and outside of cellular entities resulting in gradients depleting these from bone, tissues and myelin synthesis, while ca2+ is depleted from eNOS/nNOS which would produce Nitric Oxide otherwise for antimicrobial effect, the caveolae closes to prevent Immunological processes/communication and cellular communication from occurring, collapsing of the Sarcolemma required for muscle function, cardiac, pulmonary and other rhythms occurs, cellular entities exhibit an Amoeba Shape, tissues become more durable and cellular membranes are hardened, inhibition of PEMT occurs which also impairs antimicrobial NADPH levels, impairs RNA/DNA synthesis, impairs antihistamine response, upregulations the histamine/xenobohiotic/allergic response pathway through upregulation of Choline Kinase and CDP Choline Pathways. Uncoupling of Nitric Oxide Synthases occurs more rapidly, resulting Superoxide, H2O2, Peroxynitrite, Hypochlorite, TrimethylamineNOxide, impaired biological function and can also increase Homocysteine.

These are canonical pathways of Cardiac, Pulmonary, neurological, and otherwise exhibition of metabolic syndrome, dysfunction and infarct.

The Spanish Influenza or Le Gripe as it was known throughout Europe, move across the world, enabled by trade, migration and the conflict of 1914 to 1918, although the conflict of 1914 to 1918 may have largely occurred because of the Flexner Report of 1910, the omitting of Dimethyl Acetothetin in newly restructured health services industry beginning in about 1910, the integration into health systems of Western Nations of the medical system principles of a major participant in the conflict of 1918 to 1918, along with precise Homologues to much of the conflict and subsequent Geopolitical conflict to precise nuances of the pathogenic consequences of not implementing Dimethyl Acetothetin, thanks to the emerging of great information, in increasingly powerful information systems, including engineering of more power electronics with which to manage such information. The best way to understand how allowed Human inadequacy at nutritional, physiological, metabolic, behavioral and social levels are increased susceptibility to the influences of systems which replace the priorities of Humans for one another with the priorities of systems, such that Humans act with integral systemic priority, enabling achievement of systemic objectives over individual, group and Human priorities, all occurring in a way that can be enhanced by expansive training and application of Humanity in active geopolitical conflict compared to passive training in such systems when geopolitical conflict is not active that invariably includes no reason to mitigate Human vital being as a priority and no reason to mitigate Human priority in achievement of operational, strategic and tactical objectives.

Human susceptibility, then, can result in increase potential for interaction between systems competing for Human outcomes to satisfy quotas, objectives, and expansive priority among public perception, as well as competition between future outcomes and outcomes already occurred with alternative outcomes which could have occurred, which challenge the status quo to change those influences most prevalently exhibited among the status quo. Because all molecules, and Hydride as well, interacts and memorizes as well as persists its relationship with all factors of the Universe with which interactions have occurred, occur or will be exhibited, quantum entanglement occurs in which interactions occurring at 30,000 times the velocity light regularly link what is happening now with what has already happened and those things which are to happen. Every virus brings with it the genetic and material memory of its historical origin to the emergence of the Universes from individual loops or strings occurring the material of the Universes, into Hydrogen as H2 or Molecular Hydrogen, into Hydrogen Fractals which shepherd the production of all the elements of the periodic tables, to the origins vital being and Humanity, to the exhibition of lineages of organisms such as microbes and viruses. The Spanish Influenza utilized the emotional and economic influences, as well as shared cognitive context of the Conflict of 1914 to 1918, along with the ways these change cellular receptors, metabolic conditions and immunological function, affecting much of the world in way that did not seem to disrupt the Gompertz Makeham Sigmoid of distribution of occurrence of abated vital being. However, these merely prepared the world for a much more substantial reoccurrence after a member of Geopolitical Systems of Conflict visited a Farm in Kansas where the Spanish Influence was move into Porcine Farm Animals where it mutated with Porcine Influenza Variants, reaffected the visitor, then was transported back to Philadelphia where it was distributed among others in the same systems to become transported all across the world, demonstrating how viruses had already learned to utilize social networking as exhibited in their Universes level occurrence as a member of Microbial populations and as exhibited by their lineage of existence that is much more expansive than the duration of the Human Experience according to the scientific and other literature.

The 1918 influenza disrupted the Gompertz Makeham Sigmoid by causing populations with the Strongest Immunological Systems to become at highest risk, such that some instances of abated vital being occurred within hours of exposure. It is likely that that 1918 influenza, instead of merely exhibiting a more efficient viral harpoon with which to attach to receptors, particularly because the research now observes that Viruses stow away within Lipid receptors in Clathryn enabled and Caveolae enabled receptor pathways utilized to endocytose lipids as well as required iNOS and Phospholipase D to escape the toxic space between the inner and outer plasma membranes, to become endocytose through iNOS enabled perforations and Phospholipase D enabled Endosomes, while the Endosomes can be recycled as Lipid Distribution factors, redistributing Virions all through physiology in protected Lipid Vesicles that are taken up by Lymphatic Tissue and Cellular Entities otherwise readily, where they cause iNOS expression until iNOS becomes uncoupled, eNOS/nNOS are deprived of substrate, and the cycle of increasing impairment continues. It is very clear that merely impairing the availability of NAD+ by inhibiting PEMT, causing P53 become upregulated and thereby impairing synthesis of DNA/RNA, all of which cause depletion of NAD+ by persistent PARP and PARS signaling that is accompanied by impaired DNA repair and impaired transcription, is enough to cause S-Adenosyl Homocysteine to aggregate, iNOS to persistently occur, and the CDP Choline Pathway to be upregulate which prevents antiinflammatory Fatty Acids and Antihistamines from being synthesized through the CDP Ethanolamine to PEMT, Phosphatidylserine Synthase/Decarboxylase, Ceramide, Sphingosine 1 Phosphate, S1P Lyase, Hexadecenal and Phosphoethanolamine pathway components from containing inflammation cascades. These seem to intricately characterize at least some of the nuances of inflammatory pulmonary pathology, particularly microbial associated pathology in regard. Cystic Fibrosis, for instance, is now known to be indicated for Choline pathway supplementation in way that disrupts that Etiology of the disease.

The media coverage of the 2020 Corona Virus epidemic clearly presents, although the information is not able to independently reproduced, that each instance of abated vital being in this Nation which has occurred resultant of Corona Virus Affliction was also accompanied by other health conditions. This suggest without a doubt that increased levels of Homocysteine, iNOS, and TrimethylamineNOxide, as well as energy exposure, all were integral complicating factors in causing abated vital being. Again, managing these factors would be like managing traffic in France at the few roads the emerge from Paris, such that all of the roads which lead to Paris all across France, Europe and the World, are much more easily managed or blocked at only those roads which lead to and from Paris. Managing the empirical causality for disease becomes easily accomplished by managing the few empirical causal factors, but the destabilizing effect of doing so would disrupt pervasive aspects of the economy. A few companies producing alternatives for far fewer factors, would definitely affect the stability of very capable, trained, intelligent and important groups.

Cursory observation of the distribution of diagnosed Coronavirus and abated vital being resultant of Coronavirus and different Nations clearly exhibits correlation to the electricity consumption of Nations and how prevalent the utilization of foods are which inhibit inflammation. One Nation, in particular, with no instances of abated vital being not only exhibits comparatively lower levels of energy consumption, but such nation has a substantial rural component and potential for substantial disparities in Electricity availability as distance increases from Urban developed centers.

Resource. One chart shows different countries' current coronavirus abated vital being rates, based on the known number of diagnoses and instances of abated vital being occurrence. Business Insider.

Resource. List of Countries by Electrical Energy Consumption. World Factbook Data.

Resource. Status of Coronavirus Diagnoses in a Particular Nation as of March 18, 2020. State of Health. Health and Pharmaceuticals. Statista Website.

Resource. A Particular Nation's Coronavirus Diagnoses Rise to 57, Health Ministry. New York Times, March 16, 2020.

The Coronavirus Epidemic of 2020 was foretold by Human events. The Immigration crisis exhibited between 2016 and 2019, mimicked precisely the way in which iNOS, Energy Fields, Choline Deficiency, and Phospholipase D from these same factor enable impaired Immunological Synapse, impair eNOS/nNOS, cause involution of Immunological centers resulting in opportunistic microbial susceptibility, as well as enables transit of Microbes from the Toxic Plasma Membrane interstitial Space into the Intracellular environment, including being encapsulated in Endosomes for redistribution in lipid vesicles to other cellular entities and other areas of physiology. It is unfortunate that even those affected by such crisis share referential similar to the word iNOS. Similarly, the modality of quarantine exhibited by those entering nations to observe if there may be a microbial condition exhibited or latently exhibited, also precisely mimics modality of essential immunological synapses.

The clinical data suggests that there may numerous antiviral agents applicable in Corona Virus affliction therapy but none have been presented as Plainly indicated specifically for Corona Virus affliction. However, somewhat pervasively and inclusively, Drugs provided during primary, outpatient, inpatient, Emergency, Critical, Intensive or extended duration care, all upregulate S-Adenosyl homocysteine, Homocysteine, TrimethylamineNoxide, iNOS, Uncoupled Nitric Oxide Synthase, and Reactive Oxygen Species and Reactive molecular Species, C Reactive Protein, and other nuances of pathology. Each of these along with D Lactate/Lactic Acid, L Lactate/Lactic Acid, Methylglyoxal, and Hyperoxularia, AP1, SP1, IDO, Thrombin, or other factors, comprise the factors that cause nonresponsiveness and cessation of vital being  function. These empirical causes of disease are often omitted in care and the patient and the prudent clinician will have to manage these aloof of standard practice or alone while they are in the care setting or managing care apart from health facilities. The health industry will not treat these empirical causes of disease or acknowledge them because the more distantly therapeutics are from these, the more likely there is to exhibit defacto cooperation with other organizations developing therapeutics, preventing highly competitive, highly disruptive innovation around the core of Physiological biological, metabolic and developmental processes. The Corona Virus pandemic is giant finger pointing at the gap between these empirical causes of disease and where therapeutics development organizations are willing to produce products, such that such disparity or gap emerges from inadequacy of Hydride, Methyl Groups, Choline, PEMT and enriched Phosphatidylcholine synthesis.

First Wave Microbial epidemics can merely increase levels of abated vital being along the same shape characteristics of Gompertz Makeham, but invariably these bring along with them a memory of all the Viral DNA/RNA experience, quantum experience, and produce portals into the future as well as into antecedent eras that can change the shape of receptors in Humans and change biological function that cause relics of past epidemics and microbial behavior that change Human receptor shape and reactivity, change quantum characteristics of material, as well as integrate viral vectors into Human DNA permanently along with myriad already integrated Viral DNA in the Human Genome, such that these open the door to other vectors of pathology. The Corona Virus presents that not treating the empirical causal factors in disease not only has caused 300,000,000 instances of unnecessary abated vial being in one nation along, but continues to cause tragic outcomes. Until S-Adenosyl Homocysteine, Homocysteine below 6 or 7 Micromoles Per Liter, iNOS management, uncoupled NOS management, TrimethylamineNOxide inhibition, Choline deficiency, Methyl Group Inadequacy, Sulfur Inadequacy, and Hydride inadequacy, as well as NAD+ status, D/L Lactate/Lactic Acid, C - Reactive Protein, AP1, SP1, Thrombin, IDO, Methylglyoxal, Hyperoxularia, all become required by Executive Order, Ratification by the Legislature, and acceptance as primary standard of care in any context, Humans will continue to be subjected to unnecessary detrimental behavioral and unnecessary detrimental physiological outcomes while systems benefit from the susceptibilities to shaped and contrive behavior as well as shaped and contrived physiological outcomes which occur as a result.

Pandemics and events that potentially cause abated vital being at individual or expansive levels, pervasively, are interactions between systems in different eras which are competing for prevalence by affecting population levels and populations that are included in interactions that transcend distance location and time. Assuring Choline and managing the factors presented here as well as that presented in material with which the profile attached to the posting is associated, all increase the density of cellular entities per micrometer of tissue in organisms, particularly, humans, thereby enhancing the existential nuances of being and improving the hereness of Humans. However, moving quickly to provide required economic, social, emotional, nutritional, and other assistance to populations affected by such influences, disrupts and mitigates the ability of influences in other eras from reaching into eras of immediacy to commandeer Human outcomes to their benefit, while also moving quickly to assure vital being even as, should or if such adjudicative interactions occur, continues to enable Human perception, cognition, and function persist Human priority, regardless of what concluding resultant outcomes such interactions among systems of dynamics of Universes produce.

Prevent and treat Corona Virus using specific inhibitors of iNOS including potentially Curcumin. Manage Corona Virus with Choline 800 mg per day or 4 to 7 mg per day per kg of anatomical mass. Manage Corona Virus by taking S-Methyl Methionine Sulfonium, Trimethylglycine, Methylsulfonylmethane, Folate, 6s 5678 tetrahydrofolate, Zinc, Molybdenum, B6, B12, Niacin, Thaimin, Biotin, Riboflavin, and Pantothenic Acid. Intervene the Corona Virus by inhibiting AP1 with Berberine or specific AP1 inhibitors. Manage Corona Virus susceptibility and conditions using SP1 inhibitors such as Curcumin. Inhibit C Reactive Protein with Curcumin or inhibitors of C Reactive Protein. Manage Corona Virus by inhibiting MCP-1 or utilizing Feverfew or Curcumin. Manage risk for these conditions by taking NAD+ and NADH with NAD+ at levels much higher than NADH. Managing complications and infarct utilizing Tetrahydrobiopterin, Iron, Zinc, Catalase, Superoxide Dismutase, L-Arginine. Be sure to drink filtered water without Fluorine and without Chlorine because these cause iNOS expression, Also, manage TrimethylamineNOxide with 33DMB, Broad Spectrum Antibiotic, Olive Oil, Grapeseed Oil, Balsamic Vinegar, or Post biotic. Utilize a diverse Mineral Supplement. Utilize a diverse Vitamin Supplement. Cover all the power outlets in Homes, dwellings or treatment facilities. Remove all sources of artificial magnetic influence and energy. Turn of all mobile devices in treatment areas. Place all identification documents, including those used for travel, in metal containers because these enhance the ability for being found in the 50 to 60 hz electrical field encompassing civilization. Utilize Pink Himalayan Sea Salt instead of other salt. Keep Homes and treatment areas ventilated with fresh air. Get plenty of rest but not too much rest.

Managing Homocysteine to below 6 Micromoles Per Liter and S-Adenosyl Homocysteine to below 0.012 Micromoles Per Liter, will lower the complication rate by about 99.99 percent or more, while susceptibility will be decreased correlative to energy protection activity.

Managing iNOS should decrease the complication rate by about 75 percent. Managing Choline Deficiency and covering energy/power outlets in homes, as well as using energy protection covers or stickers on electronics and communications will assist in this capacity.

Inhibiting iNOS, SP1 and MCP with Circumin or other inhibitors with lower complication rates and drastically decrease susceptibility

AP1 is utilized by Corona Virus utilizes the N Protein pathway of AP1 activation instead of the M or Membrane Protein Pathway, while also NF kB was not activated by AP1. Also, activation of AP1 and MAPKs resulted in Interleukin 8 production and was an integral cause of Pulmonary Inflammation in Pulmonary condition produced by Corona Virus. Resource Biochem Biophys Res Commun. 2003 Nov 28;311(4):870-6. 10.4049/jimmunol.173.12.7602.

Berberine can inhibit AP1 while inhibitors of AP1 otherwise will likewise decrease complications and susceptibility.

Managing Trimethylamine-N-Oxide with 33DMB and a Probiotic or Olive Oil, Grapeseed Oil or Balsamic Vinegar, all will decrease complications and susceptibility.

Managing uncoupling of Nitric Oxide Synthases with Tetrahydrobiopterin, L-Arginine, Iron, Superoxide Dismutase, Catalase, N-Acetyl L Cysteine, Vitamin A, Vitamin C, Peroxiredoxin 6, along with Glutathione and Trimethylglycine, will ablate the infarct associated with complications.

The other factors are mentioned in this article elsewhere.

It may be important to begin with, how do pandemics, epidemics and such detrimental potential vectors emerge. It can be conclusively presented that the Corona Virus, SARS, seasonal variation in Influenza Virulence, and other such vectors, all emerge as a result status quo in health services systems and modalities of therapeutic practice. The 1878 discovery of Dimethylacetothetin resulted in exhibition of manner of depleting Homocysteine at 700 times the potency of any other therapeutic. Subsequently, it was discovered that Dimethylacetothetin is metabolized by Thetin Homocysteine Methylpherase into Methionine and Methylthioglycolic Acid. Methylthioglycolic Acid was then found to perform as Inorganic to Organic Phase Separation and Transfer Agent, separating biotic phases from abiotic phases, eluting biotic potential molecules from abiotic environments, transferring biologically useful molecules into biotic phases, and integrating with particular nuances of sulfur eluting and hydride eluting factors such as particular heavy metals such as mercury to perform as synergistic toxicity management factor along with Methylation, Sulfur, Selenium, and other pathways. Thioglycolic Acid elutes diverse biologically useful molecules when presented to any of somewhat unlimited circumstances, material, solutions or environment, such that it was utilized to produce pervasive aspect of therapeutic molecules, drugs, and other factors utilized in medicine beginning in about 1900 until recent times. The enzymes which would be assisted by Dimethyl Acetothetin's lowering of Homocysteine and lowering of Homocysteine, thus, were allowed to become increasingly impaired in order to produce useful therapeutic molecules that could be marketed and sold as tens or hundreds of thousands of potential therapeutics, instead of merely providing Dimethyl Acetothetin and other metabolites in these foundational pathways.

The enzyme PEMT is required to inhibited or impaired in all disease and molecules which inhibit PEMT comprise the primary way in which behavioral health conditions, detrimental behavior, disease, Microbial disease, microbes and persistent injury or impairment, all are able emerge, persist, progress, impaired detriment and elude biological prevention and repair capabilities. PEMT is the primary enzyme impaired when the assistance of Dimethyl Acetothetin and other depletors of Homocysteine are not prioritized in care. These enzymes to assure function for include PEMT, Methionine Synthase, Methionine Synthetase, BHMT, BHMT2, Thetin Homocysteine Methylpherase, INMT, Cystathionine Beta Synthase, Cystathionine Gamma Lyase, S-Adenosyl Homocysteine Hydrolase, and others.

S-Adenosyl Homocysteine, Homocysteine are the primary pathogenic indicator, although Trimethylamine-N-Oxide, AP1, SP1, Thrombin, Inducible Nitric Oxide Synthase, Uncoupling of Any Nitric Oxide synthase, IDO, Peroxynitrite, Hypochlorite, Homocysteic Acid provide a good perspective of many of these detrimental factors which diverge into the thousands of different causes of disease, detrimental behavior, risk for sudden adverse health events, complications, and adverse Human outcomes that supply systems with endless supply of unfortunate Human outcomes that do not have to understood, their causalities not required to be acknowledged, and fill systems which managed unfortunate Human outcomes. The deterioration of brain, neurological systems, conditioning, memory, the rewards systems, social behavior at organism level and cellular level required for anatomical systems and civilization's systems to exhibit Human priority, all become impaired, enabling systems to impose their own objectives on each individual Human, supplantingly of intrinsic inclination, and enabling all of the shapes, smells, stimuli, tastes and associations that would lead to alleviating Homocysteine in nature, all becoming utilized to enable satisfaction of systemic goals, objectives and quotas. These enable Humans to become dispensable, incipient causalities ignored, and outcomes being considered only where they emerge as detrimental, obfuscating the way in which intervening Human outcomes as they emerge with opinion, social constructs, and sanctions as well as empirical therapeutics, all merely enhance the potential for even more detrimental outcomes to occur.

Even gestational phase Humans have been allowed to be choline Deficient, producing early deterioration of Human potential that results in patterns of unfortunate outcomes observed in civilization. However, homocysteine below 6 micromoles per liter is correlated with 500 to 1 decrease in abated vital being and less than optimal Human outcomes in populations of about 10,000 over a decade of observation. Pervasively, psychiatric, psychological, behavioral, genetic, progressive and sudden adverse health conditions are foundationally produced by the factors associated with increased levels of Homocysteine. Almost every disease including the detrimental factors associated with aging and the factors that occur requisitely when abated vital being occurs, all are causally linked to the factors presented here which affect Homocysteine levels, including what is wrongly known as abated vital being from natural causes. These factors are omitted from much of care including care in extended duration centers or health facilities otherwise such that resultant impairment of immunological capabilities results manifestation, mutation, and development of resistant, intelligent, resilient Microbial factors resultant of the way in which Homocysteine is correlative to age, correlative to pathology and correlated to involution or deterioration of Thymic, Hepatic, Splenic, Renal, Glandular, and Lymphatic immunological centers. The Corona and SARS microbial conditions are specifically the result of not treating the cause of Human disease, not protecting populations from Choline deficiency and synthetic energy fields, as well as the omitting of therapeutic modalities available since 1878.

Most importantly, homocysteine is not managed, introduced as education during all care, and prioritized in care because it would drastically reduce detrimental Human outcomes, such that allowing it proliferate obfuscates or obscures how drugs and therapeutics pervasively can merely increase Homocysteine and inhibit essential enzymes as well as obscuring the fact that increased levels of Homocysteine boost levels of impairment, increase how substantial sudden adverse events are, increase sudden adverse health events, enable higher case mix ratios for DRG payment, increase the percentage of length of stay and level of impairment statistics that enable outlier payments, and assist health facilities in meeting revenue and margin quotas, while health services practitioners whom manage homocysteine become at risk because they have lower recidivism rates for health consumers are ranked lower in performance stack rankings in the increasingly business entity owned health services practices because their revenue generation is lower than other practitioners.

The culminating phases of these dynamics are that in sudden adverse health events, the industry has emerged to exhibit such exorbitantly priced services and capabilities that hardly any individual is capable of paying for such services without health coverage and may not be able to pay for services even with health services coverage. Resultantly, by not treating or alleviating Homocysteine associated pathology and enabling pathways inhibited by Homocysteine to function, abated vital being is being allowed to emerge and occur, such that caregivers and those associated with individuals incurring such expensive care, all are required to acquiesce to obfuscative, uninformed, recommendations to abate vital being by withholding extensive, restorative and regenerative care. The increased level of impairment and increased risk of such adverse outcomes are utilized along with care that is impractically expensive to generate costs for care that are so unmanageable that such costs are utilized to sequester the assets, property, economic and other resources of cared for individuals and those whom they are associated with, causing detrimental economic conditions, economic and social spirals, deterioration of communications, redistribution of wealth, eradicating of the small nuances of wealth that particular groups may have acquired, and result in systems of enhance conditions of susceptibility to detrimental behavior and detrimental health outcomes.

The clinical literature clearly observes Acute Respiratory Syndrome and Neurological Deterioration are essential clinical features in the exhibition of Abated Vital Being with the Corona Virus and other similar Viral Vectors. These are clearly consistent with Pattern of diffuse Homocysteine and Inducible Nitric Oxide Synthase associated pathology. 10.1128/JVI.00737-08

These analyses observe that, like iNOS which inhibits Viral Vectors, S-Adenosyl Homocysteine also inhibits Corona Virus and other viral vectors, but the antimicrobial effect is intended to be highly specific to only particular vectors and comes at a very substantial resultant detriment to physiology, such the iNOS and S-Adenosyl Homocysteine may become upregulated resultant of SARS and Corona Virus Conditions, as well as resultant of Xenobiotics, Toxins or Microbial vectors otherwise. Prolonged exhibition of iNOS and S-Adenosyl homocysteine, as well as Homocysteine, would result in exhibition of Pulmonary Impairment, Inflammation and Neurological/Axonal Deterioration, Demyelination and other conditions. Virus Res. 2014 Dec 19; 0: 191–199.

Ebola Virus, as an example in its virulence, is inhibited substantially merely by inhibiting S Adenosyl Homocysteine Hydrolase which results preventing S-Adenosyl Homocysteine from begin translated into Homocysteine, depriving the virus of Homocysteine which is directed toward gene transcription and inflammation as well as causing accumulation of S Adenosyl Homocysteine that may be directed toward alternative Pathways such as INMT, Mitochondrial Oxidation or other pathways, as well as Proteolysis. However, S-Adenosyl Homocysteine is toxic and can begin the process of deteriorating biologically essential enzymes along with deterioration pathogenic molecules. Antiviral Res. 2000 Feb;45(2):135-47

The Studies present the Nitric Oxide is potent inhibitor of SARS and Corona virus correlated viral Vectors. Although the literature is often vague in presenting clear understanding that eNOS and nNOS, as well as PEMT enabled Pentose Phosphate Pathway NADPH, Methylation, PEMT metabolites otherwise such as caustic PMME, PDME and Phosphatidylcholine, Omega-3 Fatty Acids, etc, all are potent microbial management capabilities, such that iNOS seems to have been intended to replenish Nitric Oxide into the Plasma Membrane Interstitial Space to enhance toxicity to microbes and intended to improve the turgor of cellular entities challenged from massive apoptosis resultant of choline deficiency which results in levels of cellular entities per micrometer of tissue becoming pathogenically decreases. Nitric Oxide Synthase deteriorates cellular entities, eNOS function, and nNOS function, as well as cellular structure, and physiology, along with sequestering of Calcium from Bones and sequestering of L-arginine from Myelin Basic Protein utilized in Myelin Synthesis.

DOI: 10.1128/JVI.79.3.1966-1969.2005

Because, even during emergency care, homocysteine is not adequately prioritized and because even though Homocysteine correlated pathways are pervasively required or primary causes of the clinical statuses assayed during determination of the vital being status of impaired patients, these analysis conclude that the Corona Virus and Sars Virus are merely ancillary nuances of the systematic deprivation of Human nutritional, supplemental, and social requirements which results in every detrimental outcome observed in civilization. The known elements of such deprivation are pervasively referred to in the literature, clinical data and research, and programs endeavoring to alleviate such inadequacies, but the persistence of such factors, even during emergency care when therapeutics utilized pervasively merely increase a most prominent molecular causal factor of Human behavioral, molecular, metabolic, physiological, and anatomical susceptibility which is known as S Adenosyl Homocysteine, Homocysteine and Homocysteic Acid as well as correlated inhibition of the anatomically and regeneratively essential enzyme know as PEMT, including supply of Molecular Hydrogen, Hydride and Hydrogen Fractals through assurance of Methyl Groups to PEMT using Choline, Thetins, Dimethyl Acetothetin, and S Adenosyl Methionine.

It is important to regard emerging viral and Microbial vectors as Social Microbial Vectors because they can rely upon patterns of influence, changing of behavior, polymorphism of cellular receptors, changes to lipid metabolism and lipid receptors, all produced by the influence of energy fields, nutritional status, communications systems, and social networks. Like the way in which the 1918 influenza emerged upon two major vectors, Choline deficiency in less developed areas, accompanying conditions, and emerging of energy infrastructure in developed civilizations to caused those with the strongest most competent and capable immunological systems to be at the most substantial risk, emerging microbial factors likewise rely upon the twists, turns, and inversion of physiological capabilities as physiology manages the stack of pathologies that emerge from Choline deficiency, environmental factors, and including energy fields. The material exhibited on the Linked In Profile associated with the posting provides very intricate detail of these twists and turns of pathology that comprise the stack of pathological factors from quantum, to cellular, structural, metabolic and to environment levels.

Inducible Nitric Oxide Synthase is known to cause Demyelination by depleting intracellular Ca2+ and L-arginine as well as working with PI3K to produce perforations in the Endoplasmic Reticulum, inner Plasma Membrane and Outer Plasma Membrane, thereby depleting Store Operation Ca2+ and L-Arginine as well depleting extracellular and systemic Ca2+ and L-Arginine. These are known to promote Demyelination associated inflammation.

10.1128/jvi.74.16.7683-7686.2000. Curcumin or a pharmacological factor, as well as other factors can inhibit iNOS. iNOS, however, can be derived independent of viral pathology from Choline inadequacy, energy fields, chlorine and fluorine in water, lipopolysaccharide, and change in gravitational fields, as well as from deep tissue injury and expression of Estetrol near an early developing gestational Human.

iNOS is known sequester Ca2+ and L-Arginine from intracellular and extracellular environment, causing the Caveolae to become constricted, eNOS/nNOS both to become deactivated from inadequate Ca2+, as well as causing eNOS/nNOS and iNOS itself to become uncoupled, producing reactive molecular species, inhibiting PEMT, upregulating the CDP-Choline Pathway through Choline Kinase, all of which constitute infarct at the cellular level, Neurological Level, organ and tissue level, explaining compaction, pulmonary dysbiosis and impaired system function in these microbial conditions. Although Methylglyoxyl and dysbiosis define Sepsis from Microbial Levels, it is the infarct that may be the physiological manifestation of such detriment, other than metabolic syndrome exhibited by the Pathology Stack. Methylglyoxal and Hyperoxaluria can be managed by Magnesium, L-Arginine and citrate or Magnesium Citrate.

Viral Vectors are known to utilize Lipid Receptors to enable Endocytosis of Virions as well as utilize Endosomes produced from inner plasma membrane from Energy Fields, Phospholipase D, iNOS, Choline Deficiency and the way in which Energy fields cause Cholesterol to become deposited differently according to Ponderomotive Forces to escape the toxicity to viral vectors exhibited in the plasma membrane interstitial space exhibited between the inner plasma membrane and the outer plasma membrane. Resultantly, Viruses escape toxicity and become endocytosed as well as become including when Endosomes are recycled for the redistribution of lipids and molecular messengers between cellular entities and tissues through gap junction proteins as well as the excretory, secretory and endocytosis receptors.

Energy free therapeutic environments, Phospholipase D inhibitors, Choline Supplementation and removal of information regarding patients from internet websites, mobile devices, and computing systems such as removing mobile phone numbers and address from internet linked systems, all can relieve the way in which physiology is affected by the 50 to 60 Hz field which encompasses all of civilization. Although it is possible that iNOS produced from energy fields might be incipiently beneficial because it flushes the intracellular environment of microbes, sustained exposure to synthetic light and energy causes exhibition of impairing metabolic syndrome and causes susceptibilities to emerge in which iNOS, eNOS, nNOS all quickly proceed to uncoupled statuses, resulting Superoxide, H2O2, Peroxynitrite, Hypochlorite and TrimethylamineNOxide, which together comprise the most pervasive cause of sudden adverse health events, sudden adverse behavior, conclusion of vital being and abated vital being often mischaracterized as natural or mischaracterized as being the result of a morbidity.

The literature observes demyelination in the context of inhibited iNOS, suggesting other modalities. Correlatively, Homocysteine is known to cause demyelination directly to Myelin Sheaths, compared to iNOS which disrupts Myelin Basic Protein Synthesis by depleting L-Arginine which is major molecular constituent of Myelin.

10.3988/jcn.2014.10.4.281.

Homocysteine is able to be managed with Choline, 6s 5678 Tetrahydrofolate, Dimethylaceotothetin, Trimethylsulfonium, Dimethyl Sulfide, Trimethylglycine, S-Methylmethionine, Methylsulfonylmethane, Zinc, Cobalamin, Molybdenum, Iron, B12 Methylcobalamin, B6, Niacin, Methyltetrahydrofolate at levels less than 6s 5678 Tetrahydrofolate, NAD+, as well as inhibition of AP1, inhibition of SP1, and downregulation of other inhibitors of PEMT.

Particular vectors of Microbial Pathogenic disease and syndrome have applicability in this context.

SARS CoV is known to activate the AP1 pathway through its Nucleus NonCanonical, Nonmembrane pathway that excludes activation of Nf KB.

10.1016/j/bbrc.2003.10.075. Berberine or and AP1 inhibitors, as well as other factors inhibit AP1.

SP1 is expressed, has transactivation role and has cofactor activation roles in particular vectors of viral pathology. 10.1038/srep25754.

SP1 has at least four activation sites in the HIV Promoter region, suggesting that it strongly inhibits the enzyme PEMT and strongly upregulates the CDP Choline Pathway. J Virol. 1996 Oct; 70(10): 6665–6672.

Corona Virus produces factors that impair and impede transcription in Pulmonary Cellular entities. 10.1128/JVI.02520-12.

AP1 and SP1 are integral activators of Pulmonary Inflammation and Pulmonary Fibrosis beginning early in Corona Virus Pathology. Resource. 10.1038/srep25754.

Pregnenolone can specifically upregulate the antihistamine Ethanolamine Pathway to PEMT activation while downregulation the CDP Choline pathway which is upregulated by AP1, SP1 and inhibited PEMT.

The particular microbial vectors included for analysis here exhibits upregulated levels of MCP1, which can be managed with feverfew, curcumin or a pharmacological MCP1 inhibitors. Resources. 10.1016/S0140-6736(20)30183-5. 10.1038/srep25754

MCP1 exhibition is an incipient factor in pulmonary inflammation resultant of Coronavirus Affliction. 10.1128/JVI.80.6.2684-2693.2006

 

Bindirit inhibits MCP1 and Bindirit has been utilized to prevent bone loss in CHKV Viral Affliction. Resource. 10.1128/JVI.02034-14.

Interleukins are also upregulated by the viral vectors presented in this analysis.

C-Reactive Protein upregulation is an "important" feature of the viral vector presented for analysis.

Curcumin is known inhibitor of C-Reactive Protein, as well as may be pharmacological inhibitors of C-Reactive Protein.

10.1016/S2213-2600(20)30071-0.

Inhibition of C Reactive Protein occurs with Vitamin E, aspirin, rofecoxib, and celecoxib, while other numerous inhibitors presented in the article referenced here were lipid modulators that might enhance viral activity. Cardiovasc Drug Rev. 2006 Spring;24(1):33-50.

Decreases in the major Pulmonary Phospholipids phosphatidylcholine, Phosphatidylglycerol and Phosphatidylethanolamine, all characterize another correlated viral Vector.

Managing Methylglyoxal prevent the enzymic production of Methylglyoxal from D Lactate by the enzyme Glyoxylase. Resource. ISBN. 9783954893539.

Plants exhibit scavenging of Methylglyoxal through Glyoxylase activity which produces D Lactate, followed by D Lactate Dehdyrogenase which acts upon D-Lactate presumably to produce Pyruvate although the literature presents the Electron Transport Activity of Cytochrome C in the Mitochondria as being supplied with Electrons by D Lactate Dehydrogenases. This suggests that D Lactate Dehydrogenase, Cytochrome C and Glyoxylase perform as an Electron Balancer for the Cytosol and Mitochondria. Resources. 10.1104/pp.16.01174

10.1152/ajplung.00339.2016. Increases in phosphatidylserine, phosphatidylinositol, sphingomyelin, Cholesterol and Diacylglycerol all suggest canonical inflammation pathways are activated.

Methylglyoxal has been described in the literature as a scavenger of Superoxide Anion as well as an Antiviral factor, but it has also been described as pathogenic in diabetic conditions, the best Biomarker for Sepsis, scavenged to prevent high glucose correlation to endothelial impairment, Methylglyoxal is scavenged by N-acetyl L Cysteine and aminoguanidine. Methylglyoxal integration into Advanced Glycation End Products is inhibited by Quercetin, Morin, and kaempherol, Methylglyoxal has been observed to produce pain and discomfort in small nonHuman mammal studies. Methylglyoxal scavenging can also occur through the arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) i 10.1111/j.1476-5381.2010.01017.x. Dokl Biochem Biophys. 2016 Jul;469(1):305-8. 10.1080/09168451.2017.1282805

D Lactate and D Lactic Acid Accumulation may accompany progressive conditions and conditions in the care setting. Probiotics Bifidobacterium breve Yakult and Lactobacillus casei Shirota along with galacto-oligosaccharide as a prebiotic managed D Lactate over a three year period. Int Surg. 2013 Apr-Jun; 98(2): 110–113.

Cobalamin as B12 can scavenge Nitric Oxide. B12 may have to be used at lower levels or omitted unless supplemented with high levels of L-arginine, citrulline, Iron, and Ornithine, as well as Folate. 10.1300/J092v08n02_04.

Lactate dehydrogenase inhibitor 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Neoplasm growth by inhibiting and essential pathway to Aerobic Glycolysis of the Warburg Effect, Lactate Dehydrogenase. Resource. 10.1038/s41598-019-40617-3.

However, the downregulation of CytidylylCholine and Phosphoethanolamine, both suggest that Phosphocholine and Choline Kinase may be upregulated while production of Pulmonary Essential Cytidylylcholine is impaired, presenting introduction of an external mechanism to AP1, SP1, iNOS and Choline Kinase which is disrupting CDP Choline Phosphotransferase activity which would produce Cytidylyl Choline.

Managing S-Adenosyl Homocysteine, Homocysteine, AP1, SP1, iNOS, and TrimethylamineNOxide, as well as assuring Choline, Folate, S-Methionine Sulfonium, all manage the primary inhibitors of the enzyme PEMT. PEMT, when transcriptionally activate, includes GENE sequences that inhibit Leukocyte Infiltration which is a Hallmark Feature of virulent Pandemic Vectors, while such gene sequences also include stimulation of Erythropoiesis, stimulation of Pioneering anatomical and regenerative development pathways, enabling of DNA/RNA synthesis, along with production of diverse antinflammatory Fatty Acyl Phospholipids. Similarly, PEMT expression inhibits P53, activating Glycolysis, dilating the caveolae, upregulates Pentose Phosphate Pathway for reactivating the 60% of NADPH molecular Defense against Microbes that becomes inhibited during PEMT inadequacy, as well as results in enabling the synthesis of Hyaluronic Acid and Cervonic Acid that both inhibit Leukocyte infiltration and transform inflammatory pathways into instruction codes for nonscarring repair and regenerative biosynthesis.

Specifically, it is known that directing of membrane phospholipids toward ceramide and sphingomyelin, result in production of Sphingosine 1 Phosphate as an oscillating mechanism which is managed by S1PLyase to prevent excessive inflammatory signaling, while S1P Lyase directs S1P toward Phosphoethanolamine and Hexadecenal.

Choline Deficiency, exposure to energy fields and exposure to fluorine and chlorine in water, all comprise canonical factors in this observational analysis of pathology.

The factors presented here all could emerge independently from Choline deficiency, exposure to energy field, and exposure to chlorine and fluorine in water, suggesting that therapeutic management of this viral vector should include management of these list of pathology features and management of these causal factors. Some of the resources and activity directed toward prevent, care and vaccines should be directed toward development CRISPR CAS9 capabilities for excision of Viral DNA and blocking of viral DNA/RNA in Antisense direction. Together with managing the pathology stack upon which viral conditions rely, CRISPR DNA Repair and DNA/RNA antisense inhibition, might provide a powerful, potent capabilities to prevent pandemics while also producing therapeutic vectors which are resilient to rapid changes to viral vectors which can emerge opportunistically to circumvent therapeutic vectors.

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